{"doi":"10.1073/pnas.2119381119","title":"Cell size and polarization determine cytokinesis furrow ingression dynamics in mouse embryos","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>The final step of cell division, termed cytokinesis, comprises the constriction of a furrow that divides the cytoplasm to form two daughter cells. Although cytokinesis is well studied in traditional cell systems, how cytokinesis is regulated in complex multicellular settings and during cell-fate decisions is less well understood. Here, using live imaging and physical and molecular interventions, we find that the emergence of cell polarity during mouse embryo morphogenesis dramatically impacts cytokinesis mechanisms. Specifically, the assembly of the apical domain in outer cells locally inhibits the cytokinetic machinery, leading to an unexpected laterally biased cytokinesis.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":42237,"datarank":0.7325566738810543,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.2758783082225407,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.2758783082225407,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":18,"citers_with_citation_signal":13,"citers_with_endowment":13,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":202447,"name":"Greg FitzHarris","orcid":null,"position":1,"is_corresponding":false},{"id":202446,"name":"Lia Mara Gomes Paim","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35294282","pmcid":"PMC8944651","openalex_id":"https://openalex.org/W4221074688","authors":[],"funders":[{"funder_name":"Fonds de Recherche du Québec - Santé","grant_id":"257465","title":null},{"funder_name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","grant_id":"RGPIN-2021-03008","title":null},{"funder_name":"Canada Foundation for Innovation","grant_id":"FCI-32711","title":null},{"funder_name":"Gouvernement du Canada | Canadian Institutes of Health Research","grant_id":"PTJ173323","title":null},{"funder_name":"Canadian Institutes of Health Research","grant_id":"unidentified","title":"unidentified"},{"funder_name":"CIHR","grant_id":"","title":null},{"funder_name":"CIHR","grant_id":"","title":null}],"total_grants":7,"fwci":2.0957,"citation_percentile":0.85857513,"influential_citations":0,"citation_trend":[{"year":2022,"count":2},{"year":2023,"count":5},{"year":2024,"count":8},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"green","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8944651","host_type":"repository"},{"url":"https://doi.org/10.1073/pnas.2119381119","host_type":"HYBRID"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8944651","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.2119381119","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35294282","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8944651","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8944651?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.1073/pnas.2119381119","host_type":""}],"fields_of_study":["Cellular Mechanics and Interactions","Microtubule and mitosis dynamics","Hippo pathway signaling and YAP/TAZ","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","Cell Division","Cell Polarity","Cell Size","Cytokinesis","Embryonic Development","Mice"],"mesh_terms":["Animals","Cell Division","Cell Polarity","Embryonic Development","Cell Size","Cytokinesis","Mice"],"keywords":["Ingression","Cytokinesis","Cleavage furrow","Cell biology","Biology","Cell division","Cell polarity","Apical constriction","Cytoplasm","Cell","Morphogenesis","Genetics","Embryo development","Contractile Ring","Furrow Ingression","Mice","Animals","Embryonic Development","Biological Sciences","Cell Size"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-14T00:18:57.560605Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}