{"doi":"10.1073/pnas.2119101119","title":"A proposed unified interphase nucleus chromosome structure: Preliminary preponderance of evidence","abstract":"Cryoelectron tomography of the cell nucleus using scanning transmission electron microscopy and deconvolution processing technology has highlighted a large-scale, 100- to 300-nm interphase chromosome structure, which is present throughout the nucleus. This study further documents and analyzes these chromosome structures. The paper is divided into four parts: 1) evidence (preliminary) for a unified interphase chromosome structure; 2) a proposed unified interphase chromosome architecture; 3) organization as chromosome territories (e.g., fitting the 46 human chromosomes into a 10-μm-diameter nucleus); and 4) structure unification into a polytene chromosome architecture and lampbrush chromosomes. Finally, the paper concludes with a living light microscopy cell study showing that the G1 nucleus contains very similar structures throughout. The main finding is that this chromosome structure appears to coil the 11-nm nucleosome fiber into a defined hollow structure, analogous to a Slinky helical spring [ https://en.wikipedia.org/wiki/Slinky ; motif used in Bowerman et al. , eLife 10, e65587 (2021)]. This Slinky architecture can be used to build chromosome territories, extended to the polytene chromosome structure, as well as to the structure of lampbrush chromosomes.","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":270950,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9132,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":934438,"name":"Angus McDonald","orcid":null,"position":1,"is_corresponding":false},{"id":311114,"name":"Hu Cang","orcid":"0000-0002-7096-2905","position":2,"is_corresponding":false},{"id":936368,"name":"Joseph Lucas","orcid":null,"position":3,"is_corresponding":false},{"id":707774,"name":"Muthuvel Arigovindan","orcid":"0000-0003-1967-792X","position":4,"is_corresponding":false},{"id":707775,"name":"Zvi Kam","orcid":"0000-0003-1306-7178","position":5,"is_corresponding":false},{"id":236081,"name":"Cornelis Murre","orcid":"0000-0003-2437-507X","position":6,"is_corresponding":false},{"id":707773,"name":"Michael Elbaum","orcid":"0000-0001-7915-5512","position":7,"is_corresponding":false},{"id":708328,"name":"John W. Sedat","orcid":null,"position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T00:27:35.206187Z","pmid":"35749363","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}