{"doi":"10.1073/pnas.2118535119","title":"Viral PB1-F2 and host IFN-γ guide ILC2 and T cell activity during influenza virus infection","abstract":"Significance The regulation of functional immune cell plasticity is poorly understood. Host environmental cues are critical, but the possible influence of pathogen-derived virulence factors has not been described. We have used reverse-engineered influenza A viruses that differ in PB1-F2 activity to analyze influenza in mice in the presence or absence of host interferon (IFN)-γ. In the absence of functional PB1-F2 and IFN-γ, lung ILC2s initiated robust IL-5 responses following viral challenge, which led to improved tissue integrity and survival. Conversely, functional PB1-F2 suppressed IL-5 + ILC2 responses and induced a dominant IL-13 + CD8 T cell response regardless of host IFN-γ. These findings demonstrate the critical interplay between the viral virulence factors and host cytokines in regulating protective pulmonary immunity during influenza virus infection.","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":259550,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9566,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":451125,"name":"Victor C. Huber","orcid":"0000-0002-2555-1322","position":1,"is_corresponding":false},{"id":718151,"name":"Jesse L. Bonin","orcid":"0009-0003-5595-3749","position":2,"is_corresponding":false},{"id":718694,"name":"Danielle Califano","orcid":null,"position":3,"is_corresponding":false},{"id":718695,"name":"Sharon L. Salmon","orcid":null,"position":4,"is_corresponding":false},{"id":278639,"name":"Andrew N. J. McKenzie","orcid":"0000-0001-9757-2512","position":5,"is_corresponding":false},{"id":672522,"name":"Dennis W. Metzger","orcid":"0000-0002-8000-9907","position":6,"is_corresponding":false},{"id":718150,"name":"Tarani Kanta Barman","orcid":"0000-0003-4121-4526","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T00:25:58.993402Z","pmid":"35169077","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}