{"doi":"10.1073/pnas.2117112119","title":"HIPK2 directs cell type–specific regulation of STAT3 transcriptional activity in Th17 cell differentiation","abstract":"Significance STAT3 (signal transducer and activator of transcription 3) is a master transcription factor that organizes cellular responses to cytokines and growth factors and is implicated in inflammatory disorders. STAT3 is a well-recognized therapeutic target for human cancer and inflammatory disorders, but how its function is regulated in a cell type–specific manner has been a major outstanding question. We discovered that Stat3 imposes self-directed regulation through controlling transcription of its own regulator homeodomain-interacting protein kinase 2 ( Hipk2 ) in a T helper 17 (Th17) cell–specific manner. Our validation of the functional importance of the Stat3–Hipk2 axis in Th17 cell development in the pathogenesis of T cell–induced colitis in mice suggests an approach to therapeutically treat inflammatory bowel diseases that currently lack a safe and effective therapy.","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":264961,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9504,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":924124,"name":"Anbalagan Jaganathan","orcid":null,"position":1,"is_corresponding":false},{"id":489876,"name":"Yuan Hu","orcid":"0000-0002-8425-9751","position":2,"is_corresponding":false},{"id":923506,"name":"Feihong Xu","orcid":"0000-0002-4120-1146","position":3,"is_corresponding":false},{"id":747249,"name":"Alannah Lejeune","orcid":"0000-0003-0822-9777","position":4,"is_corresponding":false},{"id":924125,"name":"Rajal Sharma","orcid":null,"position":5,"is_corresponding":false},{"id":809459,"name":"Cristina I. Caescu","orcid":"0000-0003-4200-2779","position":6,"is_corresponding":false},{"id":923507,"name":"Jamel Meslamani","orcid":"0000-0002-0115-1527","position":7,"is_corresponding":false},{"id":687619,"name":"Adam Vincek","orcid":"0000-0002-7976-6927","position":8,"is_corresponding":false},{"id":923508,"name":"Fan Zhang","orcid":"0000-0002-4627-7019","position":9,"is_corresponding":false},{"id":289963,"name":"Kyung Lee","orcid":"0000-0002-9756-1765","position":10,"is_corresponding":false},{"id":250426,"name":"Nilesh Zaware","orcid":"0000-0001-9649-2078","position":11,"is_corresponding":false},{"id":433078,"name":"Amina Abdul Qayum","orcid":null,"position":12,"is_corresponding":false},{"id":558533,"name":"Chunyan Ren","orcid":"0000-0002-3913-2479","position":13,"is_corresponding":false},{"id":285837,"name":"Mark H. Kaplan","orcid":"0000-0002-2923-8245","position":14,"is_corresponding":false},{"id":263575,"name":"John Cijiang He","orcid":"0000-0002-1502-2849","position":15,"is_corresponding":false},{"id":490523,"name":"Huabao Xiong","orcid":"0000-0003-0180-2104","position":16,"is_corresponding":false},{"id":228878,"name":"Ming‐Ming Zhou","orcid":"0000-0002-7049-0573","position":17,"is_corresponding":false},{"id":597955,"name":"Ka Lung Cheung","orcid":null,"position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-19T00:26:45.905331Z","pmid":"35344430","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}