{"doi":"10.1073/pnas.2114390118","title":"Monoclonal antibody-mediated neutralization of SARS-CoV-2 in an IRF9-deficient child","abstract":"We describe an unvaccinated child at risk for life-threatening COVID-19 due to an inherited deficiency of IRF9, which governs ISGF-3-dependent responses to type I and III interferons (IFN). She was admitted, with a high nasal SARS-CoV-2 load on day 1 of upper respiratory tract infection. She was viremic on day 2 and received casirivimab and imdevimab. Her clinical manifestations and viremia disappeared on days 3 and 4, respectively. Circulating SARS-CoV-2 virus induced the expression of IFN-stimulated genes in leukocytes on day 1, whereas the secretion of blood type I IFNs, which peaked on day 4, did not. Antibody-mediated SARS-CoV-2 neutralization is, therefore, sufficient to overcome a deficiency of antiviral IFNs.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":166430,"datarank":0.5375278407684165,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.0,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9553,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":104484,"name":"Peng Zhang","orcid":"0000-0002-6129-567X","position":1,"is_corresponding":false},{"id":104138,"name":"Paul Bastard","orcid":"0000-0002-5926-8437","position":2,"is_corresponding":false},{"id":104144,"name":"Karim Dorgham","orcid":"0000-0001-9539-3203","position":3,"is_corresponding":false},{"id":692072,"name":"Isabelle Melki","orcid":"0000-0002-8057-333X","position":4,"is_corresponding":false},{"id":692073,"name":"Alice Hadchouel","orcid":"0000-0001-7451-9890","position":5,"is_corresponding":false},{"id":24087,"name":"George C. Hartoularos","orcid":"0000-0001-6980-2368","position":6,"is_corresponding":false},{"id":281907,"name":"Bénédicte Neven","orcid":"0000-0001-8941-0935","position":7,"is_corresponding":false},{"id":692074,"name":"Martin Castelle","orcid":"0000-0001-9087-4411","position":8,"is_corresponding":false},{"id":692075,"name":"Charlotte Roy","orcid":"0000-0001-8274-7180","position":9,"is_corresponding":false},{"id":692966,"name":"Tom Toin","orcid":null,"position":10,"is_corresponding":false},{"id":642456,"name":"Laureline Berteloot","orcid":"0000-0001-9681-3142","position":11,"is_corresponding":false},{"id":104153,"name":"Lucy Bizien","orcid":"0000-0001-9163-9122","position":12,"is_corresponding":false},{"id":692967,"name":"Hanène Abid","orcid":null,"position":13,"is_corresponding":false},{"id":12049,"name":"Marianne Burgard","orcid":null,"position":14,"is_corresponding":false},{"id":692076,"name":"Nadhira Houhou‐Fidouh","orcid":"0000-0002-7638-2549","position":15,"is_corresponding":false},{"id":263171,"name":"Flore Rozenberg","orcid":"0000-0001-7212-2021","position":16,"is_corresponding":false},{"id":104229,"name":"Emmanuelle Jouanguy","orcid":"0000-0002-7358-9157","position":17,"is_corresponding":false},{"id":2802,"name":"Chun Jimmie Ye","orcid":"0000-0001-6560-3783","position":18,"is_corresponding":false},{"id":104228,"name":"Guy Gorochov","orcid":"0000-0003-2097-9677","position":19,"is_corresponding":false},{"id":104140,"name":"Qian Zhang","orcid":"0000-0002-9040-3289","position":20,"is_corresponding":false},{"id":57373,"name":"Jean-Laurent Casanova","orcid":"0000-0002-7782-4169","position":21,"is_corresponding":false},{"id":273547,"name":"Romain Lévy","orcid":"0000-0002-6393-0198","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:45:49.644768Z","pmid":"34702736","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}