{"doi":"10.1073/pnas.2113028118","title":"Interventional real-time optical imaging guidance for complete tumor ablation","abstract":"Significance We present an interventional optical imaging–guided oncologic technique. This interventional oncologic technique can differentiate, in vivo, the three definitive zones of tumor and tumor margin as well as normal surrounding liver, which enables differentiation of residual viable tumors from ablated nonviable tumors and thereby pretermit the intraprocedural real-time guidance for complete tumor eradication during a single interventional ablation session. This innovation should revolutionize the current ablation technology, leading to a significant advancement in the complete treatment of larger or irregular malignant lesions not only in the liver but also in other solid organs.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":187479,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9501,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":405291,"name":"Feng Zhang","orcid":"0000-0003-4556-8276","position":1,"is_corresponding":false},{"id":747638,"name":"Guanhui Zhou","orcid":null,"position":2,"is_corresponding":false},{"id":747045,"name":"Hongxiu Ji","orcid":"0000-0003-2050-4700","position":3,"is_corresponding":false},{"id":419994,"name":"Wayne L. Monsky","orcid":"0000-0003-0694-6502","position":4,"is_corresponding":false},{"id":747046,"name":"Christopher R. Ingraham","orcid":"0000-0003-1630-5856","position":5,"is_corresponding":false},{"id":42739,"name":"Chuansheng Zheng","orcid":"0000-0002-2435-1417","position":6,"is_corresponding":false},{"id":452494,"name":"Xiaoming Yang","orcid":"0000-0002-4076-3569","position":7,"is_corresponding":false},{"id":747044,"name":"Xuefeng Kan","orcid":"0000-0003-3597-4166","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-18T23:48:55.420619Z","pmid":"34611022","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}