{"doi":"10.1073/pnas.2111818119","title":"Phagocytosis and self-destruction break down dendrites of <i>Drosophila</i> sensory neurons at distinct steps of Wallerian degeneration","abstract":"Significance Mutations in the nicotinamide adenine dinucleotide (NAD + ) biosynthesis pathway are associated with progressive neurodegeneration; neuronal injury causes rapid breakdown of damaged axons and dendrites. NAD + reduction is thought to underlie both types of degeneration by inducing neuronal self-destruction. Here, we show that phagocytosis, instead of self-destruction, drives degeneration of Drosophila sensory dendrites in both injury and genetic NAD + disruptions. Mechanistically, phagocytosis is induced earlier than self-destruction by these manipulations, as a result of phosphatidylserine exposure on the dendrite surface. In addition, injured dendrites exhibit unique calcium dynamics and only partially require the axon-death factor Axed for self-destruction. Thus, our results suggest important contributions of phagocytosis to NAD + -related neurodegenerative diseases and highlight the difference between dendrite and axon degeneration.","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":247115,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9616,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":578217,"name":"Maria L. Sapar","orcid":null,"position":1,"is_corresponding":false},{"id":456424,"name":"Ankita Sarkar","orcid":"0000-0002-0970-2776","position":2,"is_corresponding":false},{"id":577668,"name":"Bei Wang","orcid":"0000-0003-3002-3302","position":3,"is_corresponding":false},{"id":422497,"name":"Chun Han","orcid":"0000-0001-7319-8095","position":4,"is_corresponding":false},{"id":422496,"name":"Hui Ji","orcid":"0000-0001-5432-8157","position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T00:23:53.369530Z","pmid":"35058357","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}