{"doi":"10.1073/pnas.2111176119","title":"Sirt6 regulates lifespan in\n            <i>Drosophila melanogaster</i>","abstract":"<jats:title>Significance</jats:title>\n          <jats:p>\n            Sirt6 is well known for its role in regulating the aging process, particularly for its ability to extend lifespan in mice when overexpressed. However, the underlying molecular mechanisms responsible for lifespan regulation by Sirt6 are not well understood. Here, we characterized dSirt6 in fruit flies (\n            <jats:italic>Drosophila melanogaster</jats:italic>\n            ). We found that dSirt6 functions very similarly to mammalian Sirt6 at the molecular and biochemical levels. Furthermore, overexpressing dSirt6 increased lifespan in flies.\n            <jats:italic>dSirt6</jats:italic>\n            overexpression extends lifespan, in part, by opposing the activity of Myc, a master regulator of protein synthesis, which is associated with decreased protein synthesis. These findings have relevance for the treatment of age-related disease by modulating Sirt6 activity.\n          </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2022,"id":25519,"datarank":0.586803450814222,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":0.0,"self_endowment_contribution":0.586803450814222,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":149953,"name":"Jason G. Wood","orcid":"0000-0003-3349-4994","position":1,"is_corresponding":false},{"id":149954,"name":"Evan Mizerak","orcid":null,"position":2,"is_corresponding":false},{"id":149955,"name":"Samuel Hinthorn","orcid":"0000-0001-6403-6852","position":3,"is_corresponding":false},{"id":149956,"name":"Julianna Liu","orcid":"0000-0002-1250-1043","position":4,"is_corresponding":false},{"id":149957,"name":"Matthew Finn","orcid":"0000-0003-2025-7500","position":5,"is_corresponding":false},{"id":149958,"name":"Sarah Gordon","orcid":"0000-0002-5342-0135","position":6,"is_corresponding":false},{"id":149959,"name":"Louis Zingas","orcid":null,"position":7,"is_corresponding":false},{"id":149960,"name":"Chengyi Chang","orcid":null,"position":8,"is_corresponding":false},{"id":149961,"name":"Mark A. Klein","orcid":"0000-0002-6782-8502","position":9,"is_corresponding":false},{"id":114903,"name":"John M. Denu","orcid":null,"position":10,"is_corresponding":false},{"id":149962,"name":"Vera Gorbunova","orcid":null,"position":11,"is_corresponding":false},{"id":149963,"name":"Andrei Seluanov","orcid":null,"position":12,"is_corresponding":false},{"id":49826,"name":"Jef D. Boeke","orcid":"0000-0001-5322-4946","position":13,"is_corresponding":false},{"id":98109,"name":"John M. Sedivy","orcid":"0000-0001-9363-4253","position":14,"is_corresponding":false},{"id":149964,"name":"Stephen L. Helfand","orcid":null,"position":15,"is_corresponding":false},{"id":149952,"name":"Jackson R. Taylor","orcid":"0000-0003-0382-6716","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35091469","pmcid":"PMC8812521","openalex_id":"https://openalex.org/W35091469","authors":[],"funders":[{"funder_name":"HHS | NIH | National Institute on Aging","grant_id":"K99AG057812","title":null},{"funder_name":"HHS | NIH | National Institute on Aging","grant_id":"AG016694","title":null},{"funder_name":"HHS | NIH | National Institute on Aging","grant_id":"AG051449","title":null},{"funder_name":"HHS | NIH | National Institute on Aging","grant_id":"AG024353","title":null},{"funder_name":"HHS | NIH | National Institute on Aging","grant_id":"AG067306","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG024353","title":null},{"funder_name":"NIA NIH HHS","grant_id":"P01 AG051449","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG067306","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG016694","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R37 AG016694","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R37 AG046320","title":null},{"funder_name":"NIA NIH HHS","grant_id":"P01 AG047200","title":null},{"funder_name":"NIA NIH HHS","grant_id":"RF1 AG024353","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG027237","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM128596","title":null},{"funder_name":"National Institutes of Health","grant_id":"7R01AG024353-02","title":"Control of Gene Expression and Life Span"},{"funder_name":"National Institutes of Health","grant_id":"5R01AG016694-04","title":"MECHANISMS OF REPLICATIVE SENESCENCE IN CELLS"},{"funder_name":"National Institutes of Health","grant_id":"1R01AG067306-01","title":"The effect of life span modifying interventions on Alzheimer's Disease in Drosophila and Mice."},{"funder_name":"National Institutes of Health","grant_id":"1K99AG057812-01","title":"Mechanisms of Lifespan Regulation by Sirt6 in Drosophila melanogaster"},{"funder_name":"National Institutes of Health","grant_id":"3P01AG051449-05S1","title":"Somatic Activation of Retrotransposition:  A new Molecular Mechanism of 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Hydrates and Related Phenomena","Geological and Geophysical Studies","Hydrocarbon exploration and reservoir analysis","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Aging","Animals","Drosophila Proteins","Drosophila melanogaster","Female","Gene Expression","Gene Expression Regulation","Haploinsufficiency","Histone Deacetylases","Longevity","Male","Sirtuins"],"mesh_terms":["Animals","Drosophila melanogaster","Histone Deacetylases","Sirtuins","Drosophila Proteins","Gene Expression","Gene Expression Regulation","Aging","Longevity","Female","Male","Haploinsufficiency"],"keywords":["Geology","Accretionary wedge","Subduction","Convergent boundary","Trench","Continental margin","Plate tectonics","Pacific Plate","Seismology","Seafloor spreading","Oceanic crust","Sedimentary rock","Continental shelf","Sedimentary basin","Basement","Thrust fault","Trough (economics)","Paleontology","Oceanography","Tectonics","Aging","Histone","MYC","Lifespan","Sirt6","Male","Longevity","Gene Expression","Haploinsufficiency","Biological Sciences","Histone Deacetylases","Drosophila melanogaster","Gene Expression Regulation","Animals","Drosophila Proteins","Sirtuins","Female"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below 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