{"doi":"10.1073/pnas.2108922118","title":"Neural mechanisms underlying the temporal control of sequential saccade planning in the frontal eye field","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>For accomplishing even the simplest of daily tasks, we execute rapid sequences of goal-directed saccadic eye movements that move from one task component to the next. Yet how the brain orchestrates such saccade sequences is not known. Using a multifaceted approach, we used behavioral analysis, neural recordings, computational modeling, and simulations to show that while the brain can program multiple action plans simultaneously, there are neural costs involved—the greater the overlap between the plans, the slower is the growth of neural activities encoding the two plans, leading to delayed response times. Our study sets up a neurophysiological framework to study action sequencing and is relevant for understanding sequencing errors observed in disorders like Parkinson’s disease.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":685204,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":281640,"name":"Naveen Sendhilnathan","orcid":"0000-0002-3534-890X","position":1,"is_corresponding":false},{"id":715139,"name":"Aditya Murthy","orcid":"0000-0002-6130-9568","position":2,"is_corresponding":false},{"id":1007675,"name":"Debaleena Basu","orcid":"0000-0003-4751-3586","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Neural mechanisms underlying the temporal control of sequential saccade planning in the frontal eye field","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>For accomplishing even the simplest of daily tasks, we execute rapid sequences of goal-directed saccadic eye movements that move from one task component to the next. Yet how the brain orchestrates such saccade sequences is not known. Using a multifaceted approach, we used behavioral analysis, neural recordings, computational modeling, and simulations to show that while the brain can program multiple action plans simultaneously, there are neural costs involved—the greater the overlap between the plans, the slower is the growth of neural activities encoding the two plans, leading to delayed response times. Our study sets up a neurophysiological framework to study action sequencing and is relevant for understanding sequencing errors observed in disorders like Parkinson’s disease.</jats:p>","is_dataset_classified":null,"base_score":2.302585092994046,"endowment":2.302585092994046,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34599104","pmcid":"PMC8501878","openalex_id":"https://openalex.org/W3161861171","authors":[],"funders":[{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS113078","title":null}],"total_grants":1,"fwci":0.8357,"citation_percentile":0.67534976,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"green","license":"https://www.pnas.org/site/aboutpnas/licenses.xhtml","oa_locations":[{"url":"https://repository.unpas.ac.id/81636/3/G.%20BAB%20II.pdf","host_type":"repository"},{"url":"https://repository.unpas.ac.id/81636/2/F.%20BAB%20I.pdf","host_type":"GREEN"},{"url":"https://repository.unpas.ac.id/81636/3/G.%20BAB%20II.pdf","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.2108922118","host_type":"publisher"},{"url":"https://repository.unpas.ac.id/81636/1/A.%20COVER.pdf","host_type":"repository"},{"url":"https://doi.org/10.1073/pnas.2108922118","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34599104","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8501878","host_type":"repository"}],"fields_of_study":["Neural dynamics and brain function","Visual perception and processing mechanisms","Neuroscience and Neuropharmacology Research","Medicine","Biology"],"mesh_terms":["Action Potentials","Animals","Haplorhini","Fixation, Ocular","Frontal Lobe","Macaca mulatta","Neurons","Photic Stimulation","Reaction Time","Saccades","Visual Fields"],"keywords":["Saccade","Saccadic masking","Neuroscience","Frontal eye fields","Eye movement","Saccadic suppression of image displacement","Supplementary eye field","Psychology","Macaque","Computer science","Artificial intelligence","Electrophysiology","Oculomotor Control","Motor Sequences","Processing Bottlenecks"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T15:59:32.562388Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}