{"doi":"10.1073/pnas.2108728118","title":"A novel class of TMPRSS2 inhibitors potently block SARS-CoV-2 and MERS-CoV viral entry and protect human epithelial lung cells","abstract":"Significance MM3122 represents an advanced lead candidate for clinical development as a novel antiviral drug for COVID-19. In addition to being novel drugs, these selective TMRSS2 inhibitors can be used as valuable chemical probes to help elucidate mechanisms of viral pathogenesis. Since TMPRSS2 plays a key role as a viral protein processing protease in the pathogenesis of other coronaviruses (SARS-CoV, MERS-CoV) as well as influenza viruses, MM3122 and this class of TMPRSS2 inhibitors hold much promise as new drugs to not only treat SARS-CoV-2 infections but also potentially represent broad-spectrum antivirals.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":148739,"datarank":0.7206031567099886,"base_score":4.804021044733257,"endowment":4.804021044733257,"self_citation_contribution":0.7206031567099886,"citation_network_contribution":0.0,"self_endowment_contribution":0.7206031567099886,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":121,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9607,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":632763,"name":"Vishnu C. Damalanka","orcid":"0000-0002-1946-1320","position":1,"is_corresponding":false},{"id":227339,"name":"Michael A. Tartell","orcid":"0000-0002-4518-4187","position":2,"is_corresponding":false},{"id":633718,"name":"Dong hee Chung","orcid":null,"position":3,"is_corresponding":false},{"id":632764,"name":"André Luiz Lourenço","orcid":"0000-0002-2805-9384","position":4,"is_corresponding":false},{"id":632765,"name":"Dustin Pwee","orcid":"0000-0003-4692-8640","position":5,"is_corresponding":false},{"id":633719,"name":"Anne E. Mayer Bridwell","orcid":null,"position":6,"is_corresponding":false},{"id":241077,"name":"Markus Hoffmann","orcid":"0000-0003-4603-7696","position":7,"is_corresponding":false},{"id":632766,"name":"Jorine Voss","orcid":"0000-0003-2139-4179","position":8,"is_corresponding":false},{"id":632767,"name":"Partha Karmakar","orcid":"0000-0002-0170-1146","position":9,"is_corresponding":false},{"id":278066,"name":"Nurit P. Azouz","orcid":"0000-0003-4969-1263","position":10,"is_corresponding":false},{"id":278067,"name":"Andrea M. Klingler","orcid":"0000-0003-0654-9996","position":11,"is_corresponding":false},{"id":106713,"name":"Paul W. Rothlauf","orcid":"0000-0002-0941-4467","position":12,"is_corresponding":false},{"id":582635,"name":"Cassandra E. Thompson","orcid":"0000-0001-6273-8113","position":13,"is_corresponding":false},{"id":633720,"name":"Melody Lee","orcid":null,"position":14,"is_corresponding":false},{"id":633721,"name":"Lidija Klampfer","orcid":null,"position":15,"is_corresponding":false},{"id":593272,"name":"Christina L. Stallings","orcid":"0000-0002-2747-5618","position":16,"is_corresponding":false},{"id":237537,"name":"Marc E. Rothenberg","orcid":"0000-0001-9790-6332","position":17,"is_corresponding":false},{"id":241083,"name":"Stefan Pöhlmann","orcid":"0000-0001-6086-9136","position":18,"is_corresponding":false},{"id":103752,"name":"Sean P. J. Whelan","orcid":"0000-0003-1564-8590","position":19,"is_corresponding":false},{"id":241385,"name":"Anthony J. O’Donoghue","orcid":"0000-0001-5695-0409","position":20,"is_corresponding":false},{"id":288757,"name":"Charles S. Craik","orcid":"0000-0001-7704-9185","position":21,"is_corresponding":false},{"id":632768,"name":"James W. Janetka","orcid":"0000-0002-9888-5411","position":22,"is_corresponding":false},{"id":228564,"name":"Matthew Mahoney","orcid":"0000-0003-3191-2128","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:42:46.224799Z","pmid":"34635581","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}