{"doi":"10.1073/pnas.2026153118","title":"A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike","abstract":"-hCD46 mice, and golden Syrian hamsters. We found that rMeV expressing stabilized prefusion S protein (rMeV-preS) was more potent in inducing SARS-CoV-2-specific neutralizing antibodies than rMeV expressing full-length S protein (rMeV-S), while the rMeVs expressing different lengths of RBD (rMeV-RBD) were the least potent. Animals immunized with rMeV-preS produced higher levels of neutralizing antibody than found in convalescent sera from COVID-19 patients and a strong Th1-biased T cell response. The rMeV-preS also provided complete protection of hamsters from challenge with SARS-CoV-2, preventing replication in lungs and nasal turbinates, body weight loss, cytokine storm, and lung pathology. These data demonstrate that rMeV-preS is a safe and highly efficacious vaccine candidate, supporting its further development as a SARS-CoV-2 vaccine.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":153497,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":68,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":651167,"name":"Piyush Dravid","orcid":"0000-0002-4790-9591","position":1,"is_corresponding":false},{"id":651168,"name":"Yuexiu Zhang","orcid":"0000-0002-3948-1425","position":2,"is_corresponding":false},{"id":652406,"name":"Sheetal Trivedi","orcid":null,"position":3,"is_corresponding":false},{"id":238849,"name":"Anzhong Li","orcid":null,"position":4,"is_corresponding":false},{"id":236191,"name":"Olivia Harder","orcid":"0000-0002-5420-0134","position":5,"is_corresponding":false},{"id":652407,"name":"Mahesh KC","orcid":null,"position":6,"is_corresponding":false},{"id":651169,"name":"Supranee Chaiwatpongsakorn","orcid":"0000-0003-3511-7359","position":7,"is_corresponding":false},{"id":243710,"name":"Ashley Zani","orcid":null,"position":8,"is_corresponding":false},{"id":241036,"name":"Adam D. Kenney","orcid":"0000-0002-9110-1178","position":9,"is_corresponding":false},{"id":278002,"name":"Cong Zeng","orcid":"0000-0003-4423-3634","position":10,"is_corresponding":false},{"id":480434,"name":"Chuanxi Cai","orcid":"0000-0003-0532-7435","position":11,"is_corresponding":false},{"id":2361,"name":"Chengjin Ye","orcid":"0000-0002-1934-9494","position":12,"is_corresponding":false},{"id":238850,"name":"Xueya Liang","orcid":null,"position":13,"is_corresponding":false},{"id":651170,"name":"Masako Shimamura","orcid":"0009-0008-9952-351X","position":14,"is_corresponding":false},{"id":278009,"name":"Shan‐Lu Liu","orcid":"0000-0003-1620-3817","position":15,"is_corresponding":false},{"id":32980,"name":"Asunción Mejías","orcid":"0000-0002-5983-8006","position":16,"is_corresponding":false},{"id":33005,"name":"Octavio Ramilo","orcid":"0000-0002-0565-5239","position":17,"is_corresponding":false},{"id":315472,"name":"Prosper N. Boyaka","orcid":"0000-0001-6857-9088","position":18,"is_corresponding":false},{"id":321300,"name":"Jianming Qiu","orcid":"0000-0001-9850-1695","position":19,"is_corresponding":false},{"id":2423,"name":"Luis Martínez‐Sobrido","orcid":"0000-0001-7084-0804","position":20,"is_corresponding":false},{"id":241044,"name":"Jacob S. Yount","orcid":"0000-0002-6128-4575","position":21,"is_corresponding":false},{"id":236197,"name":"Mark E. Peeples","orcid":"0000-0002-4582-317X","position":22,"is_corresponding":false},{"id":510473,"name":"Amit Kapoor","orcid":"0000-0002-8117-7347","position":23,"is_corresponding":false},{"id":236196,"name":"Stefan Niewiesk","orcid":"0000-0003-4487-073X","position":24,"is_corresponding":false},{"id":236198,"name":"Jiànróng Lǐ","orcid":"0000-0002-7130-1084","position":25,"is_corresponding":false},{"id":236189,"name":"Mijia Lu","orcid":"0000-0002-4438-980X","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T23:43:44.759273Z","pmid":"33688034","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}