{"doi":"10.1073/pnas.2026027118","title":"Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes","abstract":"Significance Measles remains a major cause of infant death globally. On rare occasions, measles virus infection of the central nervous system (CNS) leads to a fatal progressive inflammation of the brain many years after the initial infection. MeV isolates from such CNS infections harbors fusion (F) protein mutations that result in a hyperfusogenic phenotype. The small number of hyperfusogenic MeV-F mutants identified thus far limits our ability to understand how these mutations are selected in the context of CNS infections. We performed a saturating mutagenesis screen of MeV-F to identify a large set of mutants that would mimic the hyperfusogenic phenotype of MeV-F in CNS infections. Characterization of these mutants shed light on other paramyxoviruses known to establish chronic CNS infections.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":168556,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9502,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":697979,"name":"Takao Hashiguchi","orcid":"0000-0001-7578-7571","position":1,"is_corresponding":false},{"id":291522,"name":"Chuan-Tien Hung","orcid":"0000-0001-6899-1312","position":2,"is_corresponding":false},{"id":479355,"name":"Kristina Dobrindt","orcid":"0000-0002-6585-8513","position":3,"is_corresponding":false},{"id":21370,"name":"Kristen Brennand","orcid":"0000-0003-0993-5956","position":4,"is_corresponding":false},{"id":697980,"name":"Makoto Takeda","orcid":"0000-0002-8194-7727","position":5,"is_corresponding":false},{"id":110494,"name":"Benhur Lee","orcid":"0000-0003-0760-1709","position":6,"is_corresponding":false},{"id":291521,"name":"Satoshi Ikegame","orcid":"0000-0002-8183-3527","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-18T23:46:06.853307Z","pmid":"33903248","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}