{"doi":"10.1073/pnas.2025333118","title":"Transcriptional regulation of intermolecular Ca <sup>2+</sup> signaling in hibernating ground squirrel cardiomyocytes: The myocardin–junctophilin axis","abstract":"Significance The efficiency of excitation–contraction coupling in heart cells depends partially on the interaction between junctophilin-2 in the sarcoplasmic reticulum and caveolin-3 on T-tubules. Decreased junctophilin-2 has been linked to heart failure. Here, we found that the transcription of junctophilin-2 and caveolin-3 is controlled concurrently by the serum response factor and myocardin. During the entree into hibernation in ground squirrels, the up-regulation of myocardin boosts junctophilin-2/caveolin-3 expression and enhances the efficiency of excitation–contraction coupling. This finding not only reveals an adaptive mechanism underlying the blood-pumping power in hibernation, but also offers a strategy to correct deficient Ca 2+ signaling in heart diseases.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":177217,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":721454,"name":"Rong-Chang Li","orcid":null,"position":1,"is_corresponding":false},{"id":720846,"name":"Bin Xiang","orcid":"0000-0002-1192-5119","position":2,"is_corresponding":false},{"id":720847,"name":"Yi‐Chen Li","orcid":"0000-0003-1131-4403","position":3,"is_corresponding":false},{"id":720848,"name":"Lipeng Wang","orcid":"0000-0002-2391-3609","position":4,"is_corresponding":false},{"id":721455,"name":"Yun-Bo Guo","orcid":null,"position":5,"is_corresponding":false},{"id":720849,"name":"Jinghui Liang","orcid":"0000-0002-1425-9406","position":6,"is_corresponding":false},{"id":720850,"name":"Xiaoting Wang","orcid":"0000-0002-5050-2397","position":7,"is_corresponding":false},{"id":720851,"name":"Tingting Hou","orcid":"0009-0000-1736-9419","position":8,"is_corresponding":false},{"id":552634,"name":"Xin Xing","orcid":"0000-0001-7207-5149","position":9,"is_corresponding":false},{"id":721456,"name":"Zeng-Quan Zhou","orcid":null,"position":10,"is_corresponding":false},{"id":720852,"name":"Haihong Ye","orcid":"0000-0001-7282-6280","position":11,"is_corresponding":false},{"id":720853,"name":"Renqing Feng","orcid":"0000-0001-6164-0544","position":12,"is_corresponding":false},{"id":55700,"name":"Edward G. Lakatta","orcid":"0000-0002-4772-0035","position":13,"is_corresponding":false},{"id":720854,"name":"Zhen Chai","orcid":"0000-0003-1522-7710","position":14,"is_corresponding":false},{"id":720855,"name":"Shi‐Qiang Wang","orcid":"0000-0001-7784-4461","position":15,"is_corresponding":false},{"id":720845,"name":"Lei Yang","orcid":"0000-0002-2882-5560","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:47:28.018172Z","pmid":"33785600","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}