{"doi":"10.1073/pnas.2021945118","title":"mTORC1-chaperonin CCT signaling regulates m <sup>6</sup> A RNA methylation to suppress autophagy","abstract":"Significance N6-methyladenosine (m 6 A) is the most prevalent modification in eukaryotic messenger RNA (mRNA) and affects RNA metabolism including splicing, stability, and translation. The m 6 A methyltransferase complex (MTC) is responsible for generating the m 6 A modifications in mRNA; however, the regulation of m 6 A modification is still unclear. We have identified Mechanistic Target of Rapamycin Complex 1 (mTORC1) as a key regulator of MTC and demonstrate that mTORC1 can stabilize MTC via activation of the chaperonin CCT complex and upregulate m 6 A modification to promote the degradation of ATG transcripts. Thus, our study unveils an mTORC1-signaling cascade that regulates m 6 A RNA methylation and autophagy.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":152716,"datarank":0.6476232170304466,"base_score":4.31748811353631,"endowment":4.31748811353631,"self_citation_contribution":0.6476232170304466,"citation_network_contribution":0.0,"self_endowment_contribution":0.6476232170304466,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":74,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9614,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":637833,"name":"Jui–Hsia Weng","orcid":"0000-0002-5878-3920","position":1,"is_corresponding":false},{"id":648168,"name":"Wen Xing Lee","orcid":"0000-0002-7779-641X","position":2,"is_corresponding":false},{"id":259031,"name":"Yanhui Hu","orcid":"0000-0003-1494-1402","position":3,"is_corresponding":false},{"id":63291,"name":"Lei Gu","orcid":"0000-0001-6469-9568","position":4,"is_corresponding":false},{"id":633183,"name":"Sungyun Cho","orcid":"0009-0009-2690-2268","position":5,"is_corresponding":false},{"id":271342,"name":"Gina Lee","orcid":"0000-0002-8120-9169","position":6,"is_corresponding":false},{"id":330815,"name":"Richard Binari","orcid":"0000-0001-6155-9607","position":7,"is_corresponding":false},{"id":649008,"name":"Cathleen Li","orcid":null,"position":8,"is_corresponding":false},{"id":273760,"name":"Min Cheng","orcid":"0000-0002-2814-5805","position":9,"is_corresponding":false},{"id":648169,"name":"Ah‐Ram Kim","orcid":"0000-0001-9597-6759","position":10,"is_corresponding":false},{"id":648170,"name":"Jun Xu","orcid":"0000-0002-7963-0253","position":11,"is_corresponding":false},{"id":263372,"name":"Zhangfei Shen","orcid":"0000-0002-3707-2265","position":12,"is_corresponding":false},{"id":648171,"name":"Chiwei Xu","orcid":"0000-0003-4967-4949","position":13,"is_corresponding":false},{"id":3257,"name":"John M. Asara","orcid":"0000-0001-7450-2589","position":14,"is_corresponding":false},{"id":85690,"name":"John Blenis","orcid":"0000-0003-3622-2337","position":15,"is_corresponding":false},{"id":14957,"name":"Norbert Perrimon","orcid":"0000-0001-7542-472X","position":16,"is_corresponding":false},{"id":335330,"name":"Hong-Wen Tang","orcid":"0000-0002-8347-9891","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:43:34.972031Z","pmid":"33649236","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}