{"doi":"10.1073/pnas.2021910118","title":"The ecdysone-induced protein 93 is a key factor regulating gonadotrophic cycles in the adult female mosquito <i>Aedes aegypti</i>","abstract":"Significance In female mosquitoes, repeated blood feedings are essential for maintaining gonadotrophic cycles and serve as the basis for pathogen transmission. We demonstrate that the ecdysone-induced protein 93 (E93), a transcription factor implicated in insect metamorphic transitions, regulates reproductive switches in adult females of the major arboviral vector Aedes aegypti . E93 RNA interference before the first gonadotrophic cycle disrupts the second. E93 silencing disturbed the expression of Hormone Receptor 3 and autophagy, both essential for vitellogenesis termination. Transcriptomic analysis reveals a E93-mediated shutdown of gene expression during the end of a reproductive cycle, particularly genes linked to translation, yolk protein precursors, and metabolism. This study has advanced our understanding of the E93 role in controlling the gonadotrophic cyclicity in female mosquitoes.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":165237,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":661145,"name":"Yike Ding","orcid":null,"position":1,"is_corresponding":false},{"id":688793,"name":"Xiangyang Lu","orcid":null,"position":2,"is_corresponding":false},{"id":688217,"name":"Danqian Geng","orcid":"0009-0000-8158-1617","position":3,"is_corresponding":false},{"id":505049,"name":"Shan Li","orcid":"0000-0001-6477-3043","position":4,"is_corresponding":false},{"id":309253,"name":"Alexander S. Raikhel","orcid":"0000-0001-6361-813X","position":5,"is_corresponding":false},{"id":309254,"name":"Zhen Zou","orcid":"0000-0003-3550-7656","position":6,"is_corresponding":false},{"id":660372,"name":"Xueli Wang","orcid":"0009-0004-6119-7166","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T23:45:36.425208Z","pmid":"33593917","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}