{"doi":"10.1073/pnas.2019462118","title":"Structural basis for a bacterial Pip system plant effector recognition protein","abstract":"Significance This work examines a fundamental question of how bacteria sense plant-released chemicals. We recently identified an effector of one member of a plant-responsive PipR family of transcription factors present in many plant-associated bacteria. This compound (abbreviated HEHEAA) requires a specific transporter for import into bacterial cells. We have solved crystal structures of one component of the transporter free and bound to HEHEAA. We discovered that a close homolog of the transporter protein cannot bind HEHEAA, implying there are other effector compound(s) for the widespread PipR signaling system family. Understanding the molecular details of these plant-responsive systems could identify a means of controlling plant colonization.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":196453,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9505,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":769726,"name":"Bruna Gonçalves Coutinho","orcid":null,"position":1,"is_corresponding":false},{"id":769029,"name":"Prikshat Dadhwal","orcid":"0000-0002-4301-4766","position":2,"is_corresponding":false},{"id":769030,"name":"Yasuhiro Oda","orcid":"0000-0003-2554-7371","position":3,"is_corresponding":false},{"id":769031,"name":"Jiahong Ren","orcid":"0000-0002-1828-0480","position":4,"is_corresponding":false},{"id":731661,"name":"Amy L. Schaefer","orcid":"0000-0003-0581-054X","position":5,"is_corresponding":false},{"id":731662,"name":"E. Peter Greenberg","orcid":"0000-0001-9474-8041","position":6,"is_corresponding":false},{"id":769032,"name":"Caroline S. Harwood","orcid":"0000-0003-4450-5177","position":7,"is_corresponding":false},{"id":86983,"name":"Liang Tong","orcid":"0000-0002-0563-6468","position":8,"is_corresponding":false},{"id":351111,"name":"Shukun Luo","orcid":"0000-0002-2766-3125","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-18T23:50:15.704473Z","pmid":"33649224","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}