{"doi":"10.1073/pnas.2014195118","title":"Oncogenic HPV promotes the expression of the long noncoding RNA lnc-FANCI-2 through E7 and YY1","abstract":"Significance Persistent infections of oncogenic HPVs can lead to cervical, anogenital, and head-and-neck cancers. We report that HPV-infected cervical lesions display aberrant expression of 194 long-noncoding RNAs, including lnc-FANCI-2 . We show that, in cell and tissue cultures, lnc-FANCI-2 is induced primarily by the oncogenic HPV E7 protein via interacting with a cellular transcription factor YY1. HPV infection also increases YY1 protein expression by reducing miR-29a, which targets the 3′ UTR of YY1 RNA. In vivo and in vitro, the nearby DNA repair gene FANCI is co-upregulated. These findings highlight an aspect on how oncogenic HPV E7 contributes to pathogenesis.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":153821,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":66,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.964,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":652041,"name":"Junfen Xu","orcid":"0000-0002-2377-0775","position":1,"is_corresponding":false},{"id":652042,"name":"Yanqin Yang","orcid":"0000-0002-5186-6408","position":2,"is_corresponding":false},{"id":652043,"name":"Xiaohong Wang","orcid":"0000-0001-8628-243X","position":3,"is_corresponding":false},{"id":652044,"name":"Ethan Wu","orcid":"0009-0008-9700-3940","position":4,"is_corresponding":false},{"id":328278,"name":"Vladimır Majerčiak","orcid":"0000-0003-2907-4583","position":5,"is_corresponding":false},{"id":424917,"name":"Tingting Zhang","orcid":"0009-0006-7823-1679","position":6,"is_corresponding":false},{"id":652045,"name":"Renske D.M. Steenbergen","orcid":"0000-0002-2327-9839","position":7,"is_corresponding":false},{"id":652773,"name":"Hsu-Kun Wang","orcid":null,"position":8,"is_corresponding":false},{"id":652774,"name":"N. Sanjib Banerjee","orcid":null,"position":9,"is_corresponding":false},{"id":28483,"name":"Yang Li","orcid":"0000-0003-4022-7341","position":10,"is_corresponding":false},{"id":652046,"name":"Weiguo Lü","orcid":"0000-0003-2062-7145","position":11,"is_corresponding":false},{"id":652047,"name":"Craig Meyers","orcid":"0000-0001-8773-3976","position":12,"is_corresponding":false},{"id":652048,"name":"Jun Zhu","orcid":"0000-0002-8634-7421","position":13,"is_corresponding":false},{"id":652049,"name":"Xing Xie","orcid":"0000-0002-1636-4816","position":14,"is_corresponding":false},{"id":652050,"name":"Louise T. Chow","orcid":"0000-0001-7586-9569","position":15,"is_corresponding":false},{"id":219079,"name":"Zhi-Ming Zheng","orcid":"0000-0001-5547-7912","position":16,"is_corresponding":false},{"id":562957,"name":"Haibin Liu","orcid":"0000-0003-3601-6066","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-18T23:43:44.759273Z","pmid":"33436409","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}