{"doi":"10.1073/pnas.2013239118","title":"A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt–Robo and RGA-9b/ARHGAP–dependent mechanism","abstract":"Significance Cell migration is a central process in development, homeostasis, and disease. Among the extracellular signaling molecules that control this process are members of the Wnt family of secreted glycoproteins, which trigger distinct canonical and noncanonical pathways in responding cells. Studies in vertebrates have shown that these pathways can antagonistically regulate migration, but how they functionally interact is not known. Using the migration of the C. elegans QR neuroblast descendants as a tractable model system, we found that the two pathways converge on activators and inhibitors of the Rho family of small GTPases that mediate cell migration. Our results show that through this cross-talk mechanism, Wnt pathways can interact to tightly regulate the migration of cells to their final destinations.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":197782,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9521,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":513216,"name":"Euclides E. Fernandes Póvoa","orcid":"0000-0002-0920-7783","position":1,"is_corresponding":false},{"id":771865,"name":"Jonas Mars","orcid":"0000-0002-5904-2235","position":2,"is_corresponding":false},{"id":514026,"name":"Annabel Ebbing","orcid":null,"position":3,"is_corresponding":false},{"id":772288,"name":"Luc Schoppink","orcid":null,"position":4,"is_corresponding":false},{"id":514027,"name":"Marco C. Betist","orcid":null,"position":5,"is_corresponding":false},{"id":513217,"name":"Hendrik C. Korswagen","orcid":"0000-0001-7931-4472","position":6,"is_corresponding":false},{"id":772287,"name":"Lorenzo Rella","orcid":null,"position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T23:50:23.532351Z","pmid":"33737394","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}