{"doi":"10.1073/pnas.2012495117","title":"A biomimetic five-module chimeric antigen receptor ( <sup>5M</sup> CAR) designed to target and eliminate antigen-specific T cells","abstract":"Significance T cells are driven by five-module receptor complexes composed of a T cell receptor (TCR) module, three CD3 signaling modules, and a coreceptor module. We adapted this architecture to engineer a biomimetic five-module chimeric antigen receptor ( 5M CAR) that consists of a chimeric receptor module, composed of the antigen recognized by pathogenic T cells fused to elements of the TCR that facilitate assembly with the three CD3 modules, and a surrogate coreceptor module that enhances signaling. We show that cytotoxic T lymphocytes expressing 5M CARs can rapidly eliminate pathogenic T cells and prevent them from mediating autoimmune disease in mice. Overall, this work describes a CAR platform and its use in mitigating T cell-mediated pathologies.","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":92243,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":461467,"name":"Martin A. Thelin","orcid":"0000-0002-2232-5514","position":1,"is_corresponding":false},{"id":462572,"name":"Heather L. Parrish","orcid":null,"position":2,"is_corresponding":false},{"id":461468,"name":"Neha Deshpande","orcid":"0000-0002-7485-4629","position":3,"is_corresponding":false},{"id":461469,"name":"Mark S. Lee","orcid":"0000-0001-8281-0039","position":4,"is_corresponding":false},{"id":461470,"name":"Alborz Karimzadeh","orcid":"0000-0002-0846-8981","position":5,"is_corresponding":false},{"id":394734,"name":"Monika A. Niewczas","orcid":"0000-0003-2371-595X","position":6,"is_corresponding":false},{"id":461471,"name":"Thomas Serwold","orcid":"0000-0002-7503-0293","position":7,"is_corresponding":false},{"id":461472,"name":"Michael S. Kuhns","orcid":"0000-0002-0403-6313","position":8,"is_corresponding":false},{"id":461466,"name":"Shio Kobayashi","orcid":"0000-0001-7243-6696","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-18T22:29:54.256205Z","pmid":"33139567","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}