{"doi":"10.1073/pnas.2012075118","title":"Coupling between slow waves and sharp-wave ripples engages distributed neural activity during sleep in humans","abstract":"Hippocampal-dependent memory consolidation during sleep is hypothesized to depend on the synchronization of distributed neuronal ensembles, organized by the hippocampal sharp-wave ripples (SWRs, 80 to 150 Hz), subcortical/cortical slow-wave activity (SWA, 0.5 to 4 Hz), and sleep spindles (SP, 7 to 15 Hz). However, the precise role of these interactions in synchronizing subcortical/cortical neuronal activity is unclear. Here, we leverage intracranial electrophysiological recordings from the human hippocampus, amygdala, and temporal and frontal cortices to examine activity modulation and cross-regional coordination during SWRs. Hippocampal SWRs are associated with widespread modulation of high-frequency activity (HFA, 70 to 200 Hz), a measure of local neuronal activation. This peri-SWR HFA modulation is predicted by the coupling between hippocampal SWRs and local subcortical/cortical SWA or SP. Finally, local cortical SWA phase offsets and SWR amplitudes predicted functional connectivity between the frontal and temporal cortex during individual SWRs. These findings suggest a selection mechanism wherein hippocampal SWR and cortical slow-wave synchronization governs the transient engagement of distributed neuronal populations supporting hippocampal-dependent memory consolidation.","journal":"Proceedings of the National Academy of Sciences","year":2021,"id":153206,"datarank":0.6394019815561974,"base_score":4.2626798770413155,"endowment":4.2626798770413155,"self_citation_contribution":0.6394019815561974,"citation_network_contribution":0.0,"self_endowment_contribution":0.6394019815561974,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":70,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9412,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":581386,"name":"Haoxin Zhang","orcid":"0000-0002-8240-8960","position":1,"is_corresponding":false},{"id":581387,"name":"Jie Zheng","orcid":"0000-0002-9086-3760","position":2,"is_corresponding":false},{"id":581975,"name":"Shiting Ma","orcid":null,"position":3,"is_corresponding":false},{"id":246338,"name":"Bryce A. Mander","orcid":"0000-0002-0831-7980","position":4,"is_corresponding":false},{"id":581388,"name":"Olivia Kim McManus","orcid":"0000-0002-4785-7795","position":5,"is_corresponding":false},{"id":581976,"name":"Sumeet Vadera","orcid":null,"position":6,"is_corresponding":false},{"id":413346,"name":"Robert T. Knight","orcid":"0000-0001-8686-1685","position":7,"is_corresponding":false},{"id":554007,"name":"Bruce L. McNaughton","orcid":"0000-0002-2080-5258","position":8,"is_corresponding":false},{"id":255541,"name":"Jack J. Lin","orcid":"0000-0003-1304-227X","position":9,"is_corresponding":false},{"id":581385,"name":"Ivan Skelin","orcid":"0000-0002-7119-9729","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:43:39.820288Z","pmid":"34001599","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}