{"doi":"10.1073/pnas.2011099117","title":"Dual self-regulated delivery of insulin and glucagon by a hybrid patch","abstract":"Reduced β-cell function and insulin deficiency are hallmarks of diabetes mellitus, which is often accompanied by the malfunction of glucagon-secreting α-cells. While insulin therapy has been developed to treat insulin deficiency, the on-demand supplementation of glucagon for acute hypoglycemia treatment remains inadequate. Here, we describe a transdermal patch that mimics the inherent counterregulatory effects of β-cells and α-cells for blood glucose management by dynamically releasing insulin or glucagon. The two modules share a copolymerized matrix but comprise different ratios of the key monomers to be \"dually responsive\" to both hyper- and hypoglycemic conditions. In a type 1 diabetic mouse model, the hybrid patch effectively controls hyperglycemia while minimizing the occurrence of hypoglycemia in the setting of insulin therapy with simulated delayed meal or insulin overdose.","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":53523,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":116,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":249304,"name":"Jinqiang Wang","orcid":"0000-0002-0048-838X","position":1,"is_corresponding":false},{"id":76208,"name":"Hongjun Li","orcid":"0000-0002-1765-8445","position":2,"is_corresponding":false},{"id":273574,"name":"Jicheng Yu","orcid":"0000-0003-3407-6671","position":3,"is_corresponding":false},{"id":237995,"name":"Guojun Chen","orcid":"0000-0002-3272-2943","position":4,"is_corresponding":false},{"id":273575,"name":"Anna R. Kahkoska","orcid":"0000-0003-2701-101X","position":5,"is_corresponding":false},{"id":273576,"name":"Valerie Wu","orcid":"0000-0003-3139-843X","position":6,"is_corresponding":false},{"id":273577,"name":"Yi Zeng","orcid":"0000-0001-8761-9719","position":7,"is_corresponding":false},{"id":237997,"name":"Di Wen","orcid":"0000-0002-5799-6422","position":8,"is_corresponding":false},{"id":273578,"name":"Jayson Miedema","orcid":"0000-0002-9204-1429","position":9,"is_corresponding":false},{"id":34495,"name":"John B. Buse","orcid":"0000-0002-9723-3876","position":10,"is_corresponding":false},{"id":238002,"name":"Zhen Gu","orcid":"0000-0003-2947-4456","position":11,"is_corresponding":false},{"id":237998,"name":"Zejun Wang","orcid":"0000-0003-0313-5819","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-18T20:45:25.145885Z","pmid":"33177238","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}