{"doi":"10.1073/pnas.2009119117","title":"A specialized population of Periostin-expressing cardiac fibroblasts contributes to postnatal cardiomyocyte maturation and innervation","abstract":"Significance During the postnatal period, the heart undergoes important changes, including cardiomyocyte cell-cycle arrest and loss of regenerative capacity. While other cell types have been better characterized, the information related to postnatal cardiac fibroblasts (CFs) is limited. Here, we report a specialized population of highly proliferative periostin-expressing (Postn+) fibroblasts in the early postnatal heart that become quiescent at P30. In comparison, P7 Tcf21+ fibroblasts have distinct gene expression from Postn+ CFs. Notably, Postn+ CFs express proliferation and neuronal-related genes, while Tcf21+ CFs preferentially express extracellular-matrix–related genes. Ablation of Postn+ cells leads to reduced cardiomyocyte growth, mitotic activity, and binucleation with increased sympathetic nerve area. Thus Postn+ cells represent a specialized developmental CF population critical for postnatal cardiac maturation.","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":58696,"datarank":0.6435689161722588,"base_score":4.290459441148391,"endowment":4.290459441148391,"self_citation_contribution":0.6435689161722588,"citation_network_contribution":0.0,"self_endowment_contribution":0.6435689161722588,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":72,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.891,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":309824,"name":"Íñigo Valiente-Alandí","orcid":null,"position":1,"is_corresponding":false},{"id":307905,"name":"Zachary M. Thomas","orcid":"0000-0001-5467-042X","position":2,"is_corresponding":false},{"id":307906,"name":"Emma J. Agnew","orcid":"0000-0003-2703-0114","position":3,"is_corresponding":false},{"id":307907,"name":"Dan Schnell","orcid":"0000-0001-5829-1830","position":4,"is_corresponding":false},{"id":307908,"name":"Allen J. York","orcid":"0000-0002-3174-0306","position":5,"is_corresponding":false},{"id":307909,"name":"Ronald J. Vagnozzi","orcid":"0000-0002-8027-1809","position":6,"is_corresponding":false},{"id":309825,"name":"Evan Meyer","orcid":null,"position":7,"is_corresponding":false},{"id":289834,"name":"Jeffery D. Molkentin","orcid":"0000-0002-3558-6529","position":8,"is_corresponding":false},{"id":271091,"name":"Katherine E. Yutzey","orcid":"0000-0002-1444-7124","position":9,"is_corresponding":false},{"id":307904,"name":"Luis Hortells","orcid":"0000-0003-1923-4918","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:07:33.416320Z","pmid":"32817558","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}