{"doi":"10.1073/pnas.2008073117","title":"POLQ suppresses interhomolog recombination and loss of heterozygosity at targeted DNA breaks","abstract":"Significance This manuscript identifies a pathway of recombination which joins DNA ends on two homologous chromosomes in human cells. This pathway supports efficient recombination at targeted DSBs and nicks, at frequencies exceeding those of the spontaneous recombination events that ameliorate genetic diseases in human blood and skin cells. Recombination is further stimulated by depletion of POLQ, a factor with both DNA polymerase and helicase activities. POLQ depletion causes an especially dramatic increase in the frequency of copy-neutral loss of heterozygosity (cnLOH) events. These results have immediate practical implications for therapeutic correction of both compound heterozygous and autosomal dominant mutations, and they identify a mechanistic origin for prominent but poorly understood mutagenic signatures in cancer.","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":100948,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":494552,"name":"Kevin J. Khoo","orcid":"0000-0001-8658-3259","position":1,"is_corresponding":false},{"id":434154,"name":"Yinbo Zhang","orcid":"0000-0002-6958-2534","position":2,"is_corresponding":false},{"id":368912,"name":"Nancy Maizels","orcid":"0000-0003-0923-4279","position":3,"is_corresponding":false},{"id":476995,"name":"Luther Davis","orcid":"0000-0002-2346-3898","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-18T22:39:01.863288Z","pmid":"32873648","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}