{"doi":"10.1073/pnas.2007194118","title":"JNK signaling prevents biliary cyst formation through a CASPASE-8–dependent function of RIPK1 during aging","abstract":"Significance JNK signaling has been studied intensively in models of liver physiology and disease, but previous studies had focused on young mice. However, it had not been recognized that JNK plays a fundamental role in maintaining liver homeostasis and preventing the formation of biliary cysts in aging mice. These observations call for caution in all long-term pharmacological inhibition strategies targeting the JNK pathway. Finally, our results provide evidence of a molecular link between JNK and the cell-death mediator RIPK1. 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