{"doi":"10.1073/pnas.2006138117","title":"Metabolic tuning of inhibition regulates hippocampal neurogenesis in the adult brain","abstract":"<jats:title>Significance</jats:title>\n          <jats:p>Our the brain actively responds to changes in the environment by remodeling neural circuits. One important aspect of neuroplasticity is adult neurogenesis, which involves the generation, survival, and incorporation of new neurons into existing circuits and is unique to two discrete areas of the mammalian brain. The hippocampus, critical for learning and memory, is one such area that exhibits ongoing neurogenesis throughout an individual’s lifetime. Although recent studies have confirmed that hippocampal behaviors regulate neurogenesis, the mechanistic pathways governing that regulatory activity remain poorly understood. In this work, we found that hippocampal behaviors increase inhibitory circuit activity through a metabolic pathway, and established a computational model to quantitively model the relationship between circuit activity and control of hippocampal neurogenesis.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":30702,"datarank":0.7508589676992563,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.2564834377986069,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.2564834377986069,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":17,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":166213,"name":"Hanxiao Liu","orcid":null,"position":1,"is_corresponding":false},{"id":166214,"name":"Johannes Morstein","orcid":"0000-0002-6940-288X","position":2,"is_corresponding":false},{"id":166215,"name":"Alexander J. 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Novak","orcid":"0000-0002-3619-018X","position":3,"is_corresponding":false},{"id":166216,"name":"Dirk Trauner","orcid":"0000-0002-6782-6056","position":4,"is_corresponding":false},{"id":166217,"name":"Qiaojie Xiong","orcid":null,"position":5,"is_corresponding":false},{"id":166218,"name":"Yuguo Yu","orcid":null,"position":6,"is_corresponding":false},{"id":127470,"name":"Shaoyu Ge","orcid":null,"position":7,"is_corresponding":false},{"id":166212,"name":"Xinxing Wang","orcid":"0000-0002-1581-4846","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.295836866004329,"endowment":3.295836866004329,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32973092","pmcid":"PMC7568294","openalex_id":"https://openalex.org/W3088544421","authors":[],"funders":[{"funder_name":"HHS | National Institutes of Health","grant_id":"NS089770","title":null},{"funder_name":"HHS | National Institutes of Health","grant_id":"AG046875","title":null},{"funder_name":"HHS | National Institutes of Health","grant_id":"NS104868","title":null},{"funder_name":"HHS | National Institutes of Health","grant_id":"DC016746","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"81761128011","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R21 NS104868","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R01 AG066912","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R21 AG046875","title":null},{"funder_name":"NINDS NIH HHS","grant_id":"R01 NS089770","title":null},{"funder_name":"NIA NIH HHS","grant_id":"R21 AG065864","title":null},{"funder_name":"NIDCD NIH HHS","grant_id":"R01 DC017470","title":null},{"funder_name":"NIDCD NIH HHS","grant_id":"R21 DC016746","title":null}],"total_grants":12,"fwci":1.7883,"citation_percentile":0.83973064,"influential_citations":0,"citation_trend":[{"year":2021,"count":7},{"year":2022,"count":3},{"year":2023,"count":4},{"year":2024,"count":8},{"year":2025,"count":2},{"year":2026,"count":2}],"oa_status":"green","license":"https://www.pnas.org/site/aboutpnas/licenses.xhtml","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7568294","host_type":"repository"},{"url":"https://www.pnas.org/content/pnas/117/41/25818.full.pdf","host_type":"BRONZE"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7568294","host_type":"repository"},{"url":"http://www.pnas.org/syndication/doi/10.1073/pnas.2006138117","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.2006138117","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.2006138117","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/32973092","host_type":"repository"}],"fields_of_study":["Neurogenesis and neuroplasticity mechanisms","Neuroscience and Neuropharmacology Research","Memory and Neural Mechanisms","Medicine","Biology","Animals","Brain","Female","Hippocampus","Lipid Metabolism","Lysophospholipids","Male","Mice","Mice, Inbred C57BL","Models, Theoretical","Neurogenesis","Neuronal Plasticity","Neurons","Sphingosine"],"mesh_terms":["Animals","Brain","Female","Hippocampus","Lysophospholipids","Male","Mice, Inbred C57BL","Models, Theoretical","Neuronal Plasticity","Neurons","Sphingosine","Lipid Metabolism","Mice","Neurogenesis"],"keywords":["Neurogenesis","Hippocampal formation","Neuroscience","Hippocampus","Neuroplasticity","Mammalian brain","Neural stem cell","Biology","Biological neural network","Inhibitory postsynaptic potential","Cell biology","Stem cell","Metabolic regulation","Tetrode Recording","Adult Hippocampal Neurogenesis","Neurocircuit"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T04:27:20.392258Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}