{"doi":"10.1073/pnas.1921698117","title":"Gene drive and resilience through renewal with next generation <i>Cleave and Rescue</i> selfish genetic elements","abstract":"Significance Gene drive can spread beneficial traits through populations, but will never be a one-shot project in which one genetic element provides all desired modifications, for an indefinitely long time. Here, we show that gene drive-mediated population modification in Drosophila can be overwritten with new content while eliminating old, using Cleave and Rescue ( ClvR ) selfish genetic elements. The ability to carry out cycles of modification that create and then leave behind a modest genetic footprint while entering and exiting a population provides important points of control. It makes possible the replacement of broken elements, upgrades with new elements that better carry out their tasks, and/or provide new functions, all while promoting the removal of modifications no longer needed.","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":65124,"datarank":0.6238324625039509,"base_score":4.1588830833596715,"endowment":4.1588830833596715,"self_citation_contribution":0.6238324625039509,"citation_network_contribution":0.0,"self_endowment_contribution":0.6238324625039509,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":63,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9523,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":344501,"name":"Tobin Ivy","orcid":"0000-0002-9116-3854","position":1,"is_corresponding":false},{"id":282110,"name":"Bruce A. Hay","orcid":"0000-0002-5486-0482","position":2,"is_corresponding":false},{"id":258211,"name":"Georg Oberhofer","orcid":"0000-0003-0930-1996","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T21:13:23.327603Z","pmid":"32245808","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}