{"doi":"10.1073/pnas.1921388117","title":"Longitudinal dynamics of the human B cell response to the yellow fever 17D vaccine","abstract":"A comprehensive understanding of the development and evolution of human B cell responses induced by pathogen exposure will facilitate the design of next-generation vaccines. Here, we utilized a high-throughput single B cell cloning technology to longitudinally track the human B cell response to the yellow fever virus 17D (YFV-17D) vaccine. The early memory B cell (MBC) response was mediated by both classical immunoglobulin M (IgM) (IgM + CD27 + ) and switched immunoglobulin (swIg + ) MBC populations; however, classical IgM MBCs waned rapidly, whereas swIg + and atypical IgM + and IgD + MBCs were stable over time. Affinity maturation continued for 6 to 9 mo following vaccination, providing evidence for the persistence of germinal center activity long after the period of active viral replication in peripheral blood. Finally, a substantial fraction of the neutralizing antibody response was mediated by public clones that recognize a fusion loop-proximal antigenic site within domain II of the viral envelope glycoprotein. Overall, our findings provide a framework for understanding the dynamics and complexity of human B cell responses elicited by infection and vaccination.","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":54455,"datarank":3.8764119578247844,"base_score":4.6443908991413725,"endowment":4.6443908991413725,"self_citation_contribution":0.6966586348712059,"citation_network_contribution":3.1797533229535784,"self_endowment_contribution":0.6966586348712059,"citer_contribution":3.1797533229535784,"corpus_percentile":null,"corpus_rank":null,"citation_count":103,"citer_count":86,"citers_with_citation_signal":73,"citers_with_endowment":73,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":true,"deposit_databanks":{"GENBANK":["MN993290","MN993593"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":109527,"name":"Denise Haslwanter","orcid":"0000-0003-2727-0468","position":1,"is_corresponding":false},{"id":279509,"name":"Yasmina Abdiche","orcid":"0009-0001-8611-2438","position":2,"is_corresponding":false},{"id":108898,"name":"Laila Shehata","orcid":"0000-0001-5037-9731","position":3,"is_corresponding":false},{"id":279510,"name":"Núria Pedreño-López","orcid":"0000-0001-6927-2301","position":4,"is_corresponding":false},{"id":279511,"name":"Crystal L. Moyer","orcid":"0000-0002-0398-6392","position":5,"is_corresponding":false},{"id":279512,"name":"Zachary A. Bornholdt","orcid":"0000-0002-7557-9219","position":6,"is_corresponding":false},{"id":109531,"name":"Asparouh Lilov","orcid":"0000-0002-4698-7264","position":7,"is_corresponding":false},{"id":109532,"name":"Juergen H. Nett","orcid":"0000-0002-1410-683X","position":8,"is_corresponding":false},{"id":109529,"name":"Rohit K. Jangra","orcid":"0000-0002-3119-0869","position":9,"is_corresponding":false},{"id":109535,"name":"Michael E. Brown","orcid":"0000-0003-3292-2117","position":10,"is_corresponding":false},{"id":279513,"name":"David I. Watkins","orcid":"0000-0001-6582-3305","position":11,"is_corresponding":false},{"id":279514,"name":"Clas Ahlm","orcid":"0000-0003-2018-8592","position":12,"is_corresponding":false},{"id":279515,"name":"Mattias N.E. Forsell","orcid":"0000-0001-6904-742X","position":13,"is_corresponding":false},{"id":279516,"name":"F.A. Rey","orcid":"0000-0002-9953-7988","position":14,"is_corresponding":false},{"id":279517,"name":"Giovanna Barba–Spaeth","orcid":"0000-0003-2069-9501","position":15,"is_corresponding":false},{"id":109548,"name":"Kartik Chandran","orcid":"0000-0003-0232-7077","position":16,"is_corresponding":false},{"id":109550,"name":"Laura M. Walker","orcid":"0000-0001-7704-3197","position":17,"is_corresponding":false},{"id":109524,"name":"Anna Z. Wec","orcid":"0000-0002-2134-2152","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-18T21:03:43.037640Z","pmid":"32152119","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}