{"doi":"10.1073/pnas.1920463117","title":"Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses","abstract":"Significance i NKT cells can both provide help and inhibit B cell responses. Our data show that when i NKT cells are activated with the glycolipid agonist αGalCer together with the inflammatory cytokine IL-18, they switch from regulating autoreactive B cells to promoting their expansion. As a consequence, autoreactive B cell responses remain unchecked by i NKT cells. The glycolipid αGalCer has been shown to have promising effects when administered as an adjuvant to achieve a better response to vaccines, as an antitumor agent, as well as in the regulation of autoimmunity. Our results highlight a facet of αGalCer-mediated i NKT cell activation in the context of inflammation and have broad implications for understanding the regulation of autoimmunity and use of αGalCer in therapy.","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":71496,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9627,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":104711,"name":"Thomas Hägglöf","orcid":"0000-0002-7751-0928","position":1,"is_corresponding":false},{"id":378090,"name":"Manasa G. Garimella","orcid":"0000-0002-9879-4480","position":2,"is_corresponding":false},{"id":699,"name":"Shan Wang","orcid":"0000-0002-8496-2092","position":3,"is_corresponding":false},{"id":378091,"name":"Amanda Duhlin","orcid":"0000-0003-1504-4789","position":4,"is_corresponding":false},{"id":378092,"name":"Ana Coelho","orcid":"0000-0001-7783-9750","position":5,"is_corresponding":false},{"id":379597,"name":"Katrine Ingelshed","orcid":null,"position":6,"is_corresponding":false},{"id":378093,"name":"Emma Mondoc","orcid":"0000-0001-9678-4126","position":7,"is_corresponding":false},{"id":378094,"name":"Stephen Malin","orcid":"0000-0001-7723-9579","position":8,"is_corresponding":false},{"id":378095,"name":"Rikard Holmdahl","orcid":"0000-0002-4969-2576","position":9,"is_corresponding":false},{"id":65713,"name":"David P. Lane","orcid":"0000-0003-0551-3545","position":10,"is_corresponding":false},{"id":378096,"name":"Elizabeth A. Leadbetter","orcid":"0000-0003-4994-6684","position":11,"is_corresponding":false},{"id":378097,"name":"Mikael C. I. Karlsson","orcid":"0000-0001-5582-614X","position":12,"is_corresponding":false},{"id":378089,"name":"Saikiran K. Sedimbi","orcid":"0000-0001-5243-8395","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T21:44:25.469842Z","pmid":"32295878","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}