{"doi":"10.1073/pnas.1920337117","title":"Cleavage-furrow formation without F-actin in\n                    <i>Chlamydomonas</i>","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>\n                    Studies of eukaryotic cell division have focused on the actomyosin ring, whose filaments of F-actin and myosin-II are hypothesized to generate the contractile force for ingression of the cleavage furrow. However, myosin-II has a very limited taxonomic distribution, whereas division by furrowing is much more widespread. We used the green alga\n                    <jats:italic>Chlamydomonas reinhardtii</jats:italic>\n                    to investigate how a furrow can form without myosin-II and the potential roles of F-actin in this process. Although F-actin was associated with ingressing furrows, its complete removal only modestly delayed furrowing, suggesting that an actin-independent mechanism (possibly involving microtubules) drives furrow ingression. Such a mechanism presumably emerged early in eukaryotic evolution and may still underlie cell division in a diverse range of modern species.\n                  </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":42262,"datarank":0.8794651388514616,"base_score":3.4965075614664802,"endowment":3.4965075614664802,"self_citation_contribution":0.5244761342199721,"citation_network_contribution":0.35498900463148947,"self_endowment_contribution":0.5244761342199721,"citer_contribution":0.35498900463148947,"corpus_percentile":null,"corpus_rank":null,"citation_count":32,"citer_count":21,"citers_with_citation_signal":15,"citers_with_endowment":15,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":202525,"name":"James G. 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