{"doi":"10.1073/pnas.1917820117","title":"Class A PBPs have a distinct and unique role in the construction of the pneumococcal cell wall","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Peptidoglycan, the main structural component of the bacterial cell wall, is made of glycan strands cross-linked by short peptides. It has long been assumed that class A penicillin-binding proteins (PBPs) are the only enzymes capable of synthesizing glycan strands from lipid II. Recently, however, it was discovered that two non-PBP proteins, FtsW and RodA, constitute the core peptidoglycan polymerizing enzymes of the divisome and elongasome, respectively. What, then, is the role of class A PBPs in the construction of the bacterial cell wall? In contrast to previous assumptions, our results strongly suggest that class A PBPs are not an intrinsic part of the divisome and elongasome but have important autonomous roles in construction of the fully mature bacterial cell wall.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":665015,"datarank":0.6394019815561974,"base_score":4.2626798770413155,"endowment":4.2626798770413155,"self_citation_contribution":0.6394019815561974,"citation_network_contribution":0.0,"self_endowment_contribution":0.6394019815561974,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":70,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1736511,"name":"Katarzyna Wiaroslawa Piechowiak","orcid":null,"position":1,"is_corresponding":false},{"id":1736512,"name":"Silje Olsen","orcid":null,"position":2,"is_corresponding":false},{"id":654900,"name":"Gro Anita Stamsås","orcid":"0000-0001-8839-2034","position":3,"is_corresponding":false},{"id":1736513,"name":"Kari Helene Berg","orcid":null,"position":4,"is_corresponding":false},{"id":654904,"name":"Morten Kjos","orcid":"0000-0003-4448-9082","position":5,"is_corresponding":false},{"id":1736514,"name":"Maria Victoria Heggenhougen","orcid":null,"position":6,"is_corresponding":false},{"id":1736515,"name":"Martín Alcorlo","orcid":"0000-0001-8337-6203","position":7,"is_corresponding":false},{"id":739840,"name":"J.A. 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Recently, however, it was discovered that two non-PBP proteins, FtsW and RodA, constitute the core peptidoglycan polymerizing enzymes of the divisome and elongasome, respectively. What, then, is the role of class A PBPs in the construction of the bacterial cell wall? 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