{"doi":"10.1073/pnas.1917278117","title":"Reply to Soulillou et al.: Difficulties in extrapolating from animal models exemplify unusual human atherosclerosis susceptibility and mechanisms via <i>CMAH</i> loss","abstract":"Soulillou et al. (1) address our report (2) regarding intrinsic and extrinsic atherosclerotic cardiovascular disease (ASCVD) in mice with human-like loss of Cmah (cytidine monophosphate- N -acetylneuraminic acid hydroxylase)––eliminating N -glycolylneuraminic acid (Neu5Gc) production. While our findings may help explain the unusual human propensity for ASCVD, extrapolation from animal models to humans has limitations. However, the intrinsic hyperimmune reactivity and diabetic tendency of these mice (refs. 3 and 4 and citations therein) are consistent with the human condition. The extrinsic mechanism involving metabolic incorporation and endogenous cell surface presentation of diet-derived Neu5Gc in humans is an example of a “xenoautoantigen”–“xenoautoantibody” reaction––which, contrary to Soulillou et al., is not induced by dietary … \n\n[↵][1]2To whom correspondence may be addressed. Email: a1varki{at}ucsd.edu or pgordts{at}ucsd.edu.\n\n [1]: #xref-corresp-1-1","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":126173,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":573573,"name":"Chirag Dhar","orcid":"0000-0002-7351-485X","position":1,"is_corresponding":false},{"id":313878,"name":"Ajit Varki","orcid":"0000-0002-2206-975X","position":2,"is_corresponding":false},{"id":106556,"name":"Philip L.S.M. Gordts","orcid":"0000-0001-7224-4328","position":3,"is_corresponding":false},{"id":501535,"name":"Kunio Kawanishi","orcid":"0000-0003-3502-3467","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:15:23.509897Z","pmid":"31964837","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}