{"doi":"10.1073/pnas.1913127117","title":"<i>Drosophila</i> as a model for studying cystic fibrosis pathophysiology of the gastrointestinal system","abstract":"Significance In this study, Kim et al. identify Drosophila CFTR ( dCFTR ) and show that knockdown of dCFTR in the adult intestine disrupts osmotic homeostasis and displays CF-like phenotypes that lead to intestinal stem cell hyperplasia. They show that expression of wild-type human CFTR , but not mutated forms of CFTR that affect protein production or transport, rescues the mutant phenotypes of dCFTR . Furthermore, global transcriptomic analysis of dCFTR fly intestine identified a mucin gene that is required for proper intestinal barrier protection. Altogether, their findings suggest that Drosophila can be a powerful model organism for studying CF pathophysiology.","journal":"Proceedings of the National Academy of Sciences","year":2020,"id":93700,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":39,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":265246,"name":"Elizabeth A. Lane","orcid":null,"position":1,"is_corresponding":false},{"id":467658,"name":"Aurelia Saftien","orcid":"0000-0001-6130-4583","position":2,"is_corresponding":false},{"id":227603,"name":"Haiyun Wang","orcid":"0000-0001-8364-8328","position":3,"is_corresponding":false},{"id":239791,"name":"Yue Xu","orcid":"0000-0002-0958-8846","position":4,"is_corresponding":false},{"id":467659,"name":"Frederik Wirtz‐Peitz","orcid":"0000-0002-7864-7280","position":5,"is_corresponding":false},{"id":14957,"name":"Norbert Perrimon","orcid":"0000-0001-7542-472X","position":6,"is_corresponding":false},{"id":467657,"name":"Kevin Kim","orcid":"0000-0002-9776-7106","position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":null,"created_at":"2026-07-18T22:31:34.149524Z","pmid":"32345720","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}