{"doi":"10.1073/pnas.1907563116","title":"The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease","abstract":"<jats:p>\n            T helper 17 (Th17) cells produce interleukin-17 (IL-17) cytokines and drive inflammatory responses in autoimmune diseases such as multiple sclerosis. The differentiation of Th17 cells is dependent on the retinoic acid receptor-related orphan nuclear receptor RORγt. Here, we identify REV-ERBα (encoded by\n            <jats:italic>Nr1d1</jats:italic>\n            ), a member of the nuclear hormone receptor family, as a transcriptional repressor that antagonizes RORγt function in Th17 cells. REV-ERBα binds to ROR response elements (RORE) in Th17 cells and inhibits the expression of RORγt-dependent genes including\n            <jats:italic>Il17a</jats:italic>\n            and\n            <jats:italic>Il17f</jats:italic>\n            . Furthermore, elevated REV-ERBα expression or treatment with a synthetic REV-ERB agonist significantly delays the onset and impedes the progression of experimental autoimmune encephalomyelitis (EAE). These results suggest that modulating REV-ERBα activity may be used to manipulate Th17 cells in autoimmune diseases.\n          </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2019,"id":13857,"datarank":2.3786302167135833,"base_score":4.465908118654584,"endowment":4.465908118654584,"self_citation_contribution":0.6698862177981877,"citation_network_contribution":1.7087439989153954,"self_endowment_contribution":0.6698862177981877,"citer_contribution":1.7087439989153954,"corpus_percentile":null,"corpus_rank":null,"citation_count":86,"citer_count":75,"citers_with_citation_signal":68,"citers_with_endowment":68,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":111999,"name":"Chin-San Loo","orcid":null,"position":1,"is_corresponding":false},{"id":59032,"name":"Xuan Zhao","orcid":"0000-0002-5778-5422","position":2,"is_corresponding":false},{"id":112000,"name":"Laura A. Solt","orcid":null,"position":3,"is_corresponding":false},{"id":112001,"name":"Yuqiong Liang","orcid":null,"position":4,"is_corresponding":false},{"id":112002,"name":"Sagar P. Bapat","orcid":null,"position":5,"is_corresponding":false},{"id":112003,"name":"Han Cho","orcid":null,"position":6,"is_corresponding":false},{"id":112004,"name":"Theodore M. Kamenecka","orcid":null,"position":7,"is_corresponding":false},{"id":112005,"name":"Mathias Leblanc","orcid":null,"position":8,"is_corresponding":false},{"id":112006,"name":"Annette R. Atkins","orcid":null,"position":9,"is_corresponding":false},{"id":112007,"name":"Ruth T. Yu","orcid":null,"position":10,"is_corresponding":false},{"id":80487,"name":"Michael Downes","orcid":"0000-0002-6351-9585","position":11,"is_corresponding":false},{"id":111920,"name":"Thomas P. Burris","orcid":null,"position":12,"is_corresponding":false},{"id":80488,"name":"Ronald M. Evans","orcid":"0000-0002-9986-5965","position":13,"is_corresponding":false},{"id":111965,"name":"Ye Zheng","orcid":null,"position":14,"is_corresponding":false},{"id":111964,"name":"Christina Chang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.465908118654584,"endowment":4.465908118654584,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31455731","pmcid":"PMC6744854","openalex_id":"https://openalex.org/W2971010702","authors":[],"funders":[{"funder_name":"Mary K. Chapman Foundation","grant_id":"Christina Chang","title":null},{"funder_name":"Albert G. and Olive H. Schlink Foundation","grant_id":"Eric Loo (Chin-San)","title":null},{"funder_name":"HHS | National Institutes of Health","grant_id":"DK096828","title":null},{"funder_name":"HHS | National Institutes of Health","grant_id":"T32 GM007198","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"Ronald M. Evans","title":null},{"funder_name":"HHS | National Institutes of Health","grant_id":"HL088093","title":null},{"funder_name":"HHS | National Institutes of Health","grant_id":"HL105278","title":null},{"funder_name":"Leona M. and Harry B. Helmsley Charitable Trust","grant_id":"2017PG-MED001","title":null},{"funder_name":"Fondation Leducq","grant_id":"Glass/Olefsky/Evans","title":null},{"funder_name":"HHS | NIH | National Institute of Environmental Health Sciences","grant_id":"P42ES010337","title":null},{"funder_name":"NOMIS Stiftung","grant_id":"Ye Zheng","title":null},{"funder_name":"National Multiple Sclerosis Society","grant_id":"RG4978-A-2","title":null},{"funder_name":"HHS | National Institutes of Health","grant_id":"AI107027","title":null},{"funder_name":"HHS | National Institutes of Health","grant_id":"OD023689","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA008748","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA014195","title":null},{"funder_name":"NIH HHS","grant_id":"S10 OD023689","title":null},{"funder_name":"NIDDK NIH HHS","grant_id":"F30 DK096828","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"R01 HL105278","title":null},{"funder_name":"NHLBI NIH HHS","grant_id":"P01 HL088093","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI107027","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI116885","title":null},{"funder_name":"National Institutes of Health","grant_id":"2P30CA014195-31","title":"Senior Leadership"},{"funder_name":"National Institutes of Health","grant_id":"5R01AI107027-07","title":"Treg development and function controlled by cis-regulatory circuits"},{"funder_name":"National Institutes of Health","grant_id":"1S10OD023689-01A1","title":"BD FACSAria Fusion for Flow Cytometry Core Facility"},{"funder_name":"National Institutes of Health","grant_id":"1F30DK096828-01A1","title":"The Role of PPAR Gamma in Fat-Resident Regulatory T Cells and Glucose Homeostasis"},{"funder_name":"National Institutes of Health","grant_id":"3P42ES010337-20S1","title":"Harnessing Technological Innovation and Community-Engaged Implementation Science to Optimize COVID-19 Testing for Women and Children in Underserved Communities"},{"funder_name":"National Institutes of Health","grant_id":"5R01HL105278-25","title":"Spatial Regulation of Developmental Gene Expression"},{"funder_name":"National Institutes of Health","grant_id":"3T32GM007198-45S1","title":"Medical Scientist Training Program"},{"funder_name":"National Institutes of Health","grant_id":"3P01HL088093-04S1","title":"Program Project: Role of Innate Immunity in Atherosclerosis"},{"funder_name":"National Institutes of Health","grant_id":"3P42ES010337-06S1","title":"Molecular Mechanisms and Models of Exposure"},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":33,"fwci":3.1487,"citation_percentile":0.92752403,"influential_citations":2,"citation_trend":[{"year":2020,"count":4},{"year":2021,"count":14},{"year":2022,"count":18},{"year":2023,"count":21},{"year":2024,"count":12},{"year":2025,"count":14},{"year":2026,"count":3}],"oa_status":"bronze","license":"CC BY NC 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ST2, and ILC Pathways","Psoriasis: Treatment and Pathogenesis","Immune Cell Function and Interaction","Biology","Medicine","0301 basic medicine","0303 health sciences","03 medical and health sciences","Amino Acid Motifs","Animals","Cell Differentiation","Encephalomyelitis, Autoimmune, Experimental","Gene Expression Regulation","Genetic Loci","HEK293 Cells","Humans","Interleukin-17","Mice","Mice, Transgenic","Multiple Sclerosis","Nuclear Receptor Subfamily 1, Group D, Member 1","Nuclear Receptor Subfamily 1, Group F, Member 3","Pyrrolidines","RNA-Seq","Response Elements","Th17 Cells","Thiophenes"],"mesh_terms":["RNA-Seq","Animals","Cell Differentiation","Encephalomyelitis, Autoimmune, Experimental","Gene Expression Regulation","Humans","Mice, Transgenic","Multiple Sclerosis","Pyrrolidines","Thiophenes","Response Elements","Interleukin-17","Amino Acid Motifs","Mice","Genetic Loci","Nuclear Receptor Subfamily 1, Group D, Member 1","Nuclear Receptor Subfamily 1, Group F, Member 3","HEK293 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