{"doi":"10.1073/pnas.1633693100","title":"Polar auxin transport in the wood-forming tissues of hybrid aspen is under simultaneous control of developmental and environmental signals","abstract":"\n Recent research has highlighted the importance of auxin concentration\n gradients during plant development. Establishment of these gradients is\n believed to involve polar auxin transport through specialized carrier\n proteins. We have used an experimental system, the wood-forming tissue of\n hybrid aspen, which allows tissue-specific expression analysis of auxin\n carrier genes and quantification of endogenous concentrations of the hormone.\n As part of this study, we isolated the putative polar auxin transport genes,\n PttLAX1\n –\n PttLAX3\n and\n PttPIN1\n –\n PttPIN3\n , belonging to the AUX1-like family of\n influx and PIN1-like efflux carriers, respectively. Analysis of\n PttLAX\n and\n PttPIN\n expression suggests that specific\n positions in a concentration gradient of the hormone are associated with\n different stages of vascular cambium development and expression of specific\n members of the auxin transport gene families. We were also able demonstrate\n positive feedback of auxin on polar auxin transport genes. Entry into dormancy\n at the end of a growing season leads to a loss of auxin transport capacity,\n paralleled by reduced expression of\n PttLAX\n and\n PttPIN\n genes.\n Furthermore, data from field experiments show that production of the molecular\n components of the auxin transport machinery is governed by environmental\n controls. Our findings collectively demonstrate that trees have developed\n mechanisms to modulate auxin transport in the vascular meristem in response to\n developmental and environmental cues.\n ","journal":"Proceedings of the National Academy of Sciences","year":2003,"id":24484,"datarank":10.101641131923783,"base_score":5.556828061699537,"endowment":5.556828061699537,"self_citation_contribution":0.8335242092549308,"citation_network_contribution":9.268116922668852,"self_endowment_contribution":0.8335242092549308,"citer_contribution":9.268116922668852,"corpus_percentile":null,"corpus_rank":null,"citation_count":258,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":146771,"name":"K. Baba","orcid":null,"position":1,"is_corresponding":false},{"id":146772,"name":"S. T. May","orcid":null,"position":2,"is_corresponding":false},{"id":146773,"name":"K. Palme","orcid":null,"position":3,"is_corresponding":false},{"id":124928,"name":"M. Bennett","orcid":null,"position":4,"is_corresponding":false},{"id":146774,"name":"R. P. Bhalerao","orcid":null,"position":5,"is_corresponding":false},{"id":146775,"name":"G. Sandberg","orcid":null,"position":6,"is_corresponding":false},{"id":146770,"name":"J. Schrader","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.556828061699537,"endowment":5.556828061699537,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12909722","pmcid":"PMC187777","openalex_id":"https://openalex.org/W2081394497","authors":[],"funders":[{"funder_name":"Biotechnology and Biological Sciences Research Council","grant_id":"G17764","title":null}],"total_grants":1,"fwci":16.3117,"citation_percentile":0.9906133,"influential_citations":15,"citation_trend":[{"year":2012,"count":12},{"year":2013,"count":15},{"year":2014,"count":11},{"year":2015,"count":11},{"year":2016,"count":12},{"year":2017,"count":10},{"year":2018,"count":13},{"year":2019,"count":13},{"year":2020,"count":9},{"year":2021,"count":10},{"year":2022,"count":13},{"year":2023,"count":11},{"year":2024,"count":9},{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/187777","host_type":"repository"},{"url":"https://europepmc.org/articles/pmc187777?pdf=render","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/187777","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1633693100","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1633693100","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12909722","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC187777","host_type":"repository"}],"fields_of_study":["Plant Molecular Biology Research","Plant Reproductive Biology","Plant nutrient uptake and metabolism","Biology","Medicine","Environmental Science","Base Sequence","Biological Transport, Active","Cloning, Molecular","DNA, Plant","Environment","Gene Expression","Genes, Plant","Indoleacetic Acids","Molecular Sequence Data","Seasons","Trees"],"mesh_terms":["Base Sequence","Biological Transport, Active","Cloning, Molecular","Environment","Indoleacetic Acids","Molecular Sequence Data","Seasons","Trees","Gene Expression","Genes, Plant","DNA, Plant"],"keywords":["Auxin","Polar auxin transport","Vascular tissue","Meristem","Biology","Cell biology","Cambium","Plant hormone","Arabidopsis","Gene","Botany","Biochemistry","Xylem","Mutant"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T22:30:34.735768Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}