{"doi":"10.1073/pnas.1615546113","title":"Normal chromosome conformation depends on subtelomeric facultative heterochromatin in\n                    <i>Neurospora crassa</i>","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>\n                    Two forms of heterochromatin, constitutive and facultative, cause gene silencing in eukaryotes. In\n                    <jats:italic>Neurospora crassa</jats:italic>\n                    , H3K27me2/3-marked facultative heterochromatin reversibly represses scores of specialized genes, whereas H3K9me3-marked constitutive heterochromatin permanently silences repetitive DNA. Interactions between heterochromatin provide a structural framework for the genome, and this is thought to be functionally important. Histone marks underlying constitutive and facultative heterochromatin are nonessential in\n                    <jats:italic>N. crassa</jats:italic>\n                    , permitting tests of their roles in genome organization and gene expression. Although linkages between regions of constitutive heterochromatin are the most prominent feature of the 3D structure of the genome, loss of the facultative mark has a much greater effect on genome architecture than does loss of key features of constitutive heterochromatin, i.e., H3K9me3 and Heterochromatin Protein 1.\n                  </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2016,"id":613306,"datarank":0.6749714505495399,"base_score":4.499809670330265,"endowment":4.499809670330265,"self_citation_contribution":0.6749714505495399,"citation_network_contribution":0.0,"self_endowment_contribution":0.6749714505495399,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":89,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":25,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":514443,"name":"Tereza Ormsby","orcid":"0000-0002-2953-9208","position":1,"is_corresponding":false},{"id":325902,"name":"Jonathan M. 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Histone marks underlying constitutive and facultative heterochromatin are nonessential in\n                    <jats:italic>N. crassa</jats:italic>\n                    , permitting tests of their roles in genome organization and gene expression. Although linkages between regions of constitutive heterochromatin are the most prominent feature of the 3D structure of the genome, loss of the facultative mark has a much greater effect on genome architecture than does loss of key features of constitutive heterochromatin, i.e., H3K9me3 and Heterochromatin Protein 1.\n                  </jats:p>","is_dataset_classified":null,"base_score":4.499809670330265,"endowment":4.499809670330265,"datacite_reuse_total":25,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27856763","pmcid":"PMC5206555","openalex_id":"https://openalex.org/W2552656428","authors":[],"funders":[{"funder_name":"HHS | NIH | National Institute of General Medical Sciences","grant_id":"GM035690","title":null},{"funder_name":"HHS | NIH | National Institute of General Medical Sciences","grant_id":"GM093061","title":null},{"funder_name":"HHS | NIH | National Institute of General Medical 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