{"doi":"10.1073/pnas.1614035114","title":"Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Metastasis is a major cause of cancer mortality. However, the regulation of this complex process remains poorly understood. Due to low oxygen supply and enhanced sugar metabolism, cancer cells releases lactate to create an acidic environment. We show that a membrane receptor on macrophages called G protein-coupled receptor 132 (Gpr132) can sense and respond to this lactate signal from cancer cells. As a result, macrophages alter their functions, which, in turn, stimulates cancer metastasis to distant organs. Consequently, loss of Gpr132 in mice inhibits breast cancer metastasis; lower Gpr132 expression in patients with breast cancer correlates with better metastasis-free survival. These findings uncover knowledge and potentially novel treatment for cancer metastasis.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2017,"id":598576,"datarank":0.9348672024825785,"base_score":6.2324480165505225,"endowment":6.2324480165505225,"self_citation_contribution":0.9348672024825785,"citation_network_contribution":0.0,"self_endowment_contribution":0.9348672024825785,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":508,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":245522,"name":"Hao Zuo","orcid":"0000-0002-8812-7385","position":1,"is_corresponding":false},{"id":292529,"name":"Hu Xiong","orcid":"0000-0003-4969-8158","position":2,"is_corresponding":false},{"id":233750,"name":"Matthew J. Kolar","orcid":"0000-0001-8054-9121","position":3,"is_corresponding":false},{"id":656576,"name":"Qian Chu","orcid":"0000-0001-6550-6975","position":4,"is_corresponding":false},{"id":17868,"name":"Alan Saghatelian","orcid":"0000-0002-0427-563X","position":5,"is_corresponding":false},{"id":225272,"name":"Daniel J. Siegwart","orcid":"0000-0003-3823-1931","position":6,"is_corresponding":false},{"id":245526,"name":"Yihong Wan","orcid":"0000-0003-0556-7017","position":7,"is_corresponding":false},{"id":243053,"name":"Peiwen Chen","orcid":"0000-0002-8129-9328","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Gpr132 sensing of lactate mediates tumor–macrophage interplay to promote breast cancer metastasis","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Metastasis is a major cause of cancer mortality. However, the regulation of this complex process remains poorly understood. Due to low oxygen supply and enhanced sugar metabolism, cancer cells releases lactate to create an acidic environment. We show that a membrane receptor on macrophages called G protein-coupled receptor 132 (Gpr132) can sense and respond to this lactate signal from cancer cells. As a result, macrophages alter their functions, which, in turn, stimulates cancer metastasis to distant organs. Consequently, loss of Gpr132 in mice inhibits breast cancer metastasis; lower Gpr132 expression in patients with breast cancer correlates with better metastasis-free survival. These findings uncover knowledge and potentially novel treatment for cancer metastasis.</jats:p>","is_dataset_classified":null,"base_score":6.2324480165505225,"endowment":6.2324480165505225,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28049847","pmcid":"PMC5255630","openalex_id":"https://openalex.org/W2567661897","authors":[],"funders":[{"funder_name":"Cancer Prevention and Research Institute of Texas","grant_id":"RP130145","title":null},{"funder_name":"U.S. Department of Defense","grant_id":"W81XWH-13-1-0318","title":null},{"funder_name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","grant_id":"R01DK089113","title":null},{"funder_name":"Mary Kay Foundation","grant_id":"#073.14","title":null},{"funder_name":"Welch Foundation","grant_id":"I-1751","title":null},{"funder_name":"HHS | NIH | National Cancer Institute","grant_id":"5P30CA142543","title":null},{"funder_name":"Cancer Prevention and Research Institute of Texas","grant_id":"R1212","title":null},{"funder_name":"Welch Foundation","grant_id":"I-1855","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA014195","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM007198","title":null},{"funder_name":"NCI NIH HHS","grant_id":"P30 CA142543","title":null}],"total_grants":11,"fwci":6.2778,"citation_percentile":0.98094574,"influential_citations":0,"citation_trend":[{"year":2017,"count":5},{"year":2018,"count":16},{"year":2019,"count":25},{"year":2020,"count":33},{"year":2021,"count":59},{"year":2022,"count":73},{"year":2023,"count":77},{"year":2024,"count":84},{"year":2025,"count":86},{"year":2026,"count":50}],"oa_status":"bronze","license":"http://www.pnas.org/site/misc/userlicense.xhtml","oa_locations":[{"url":"https://www.pnas.org/content/pnas/114/3/580.full.pdf","host_type":"journal"},{"url":"https://www.pnas.org/content/pnas/114/3/580.full.pdf","host_type":"publisher"},{"url":"http://www.pnas.org/syndication/doi/10.1073/pnas.1614035114","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1614035114","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1614035114","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28049847","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5255630","host_type":"repository"}],"fields_of_study":["Cancer, Hypoxia, and Metabolism","Immune cells in cancer","Receptor Mechanisms and Signaling"],"mesh_terms":["Animals","Breast Neoplasms","Cell Adhesion","Cell Movement","Female","Humans","Lung Neoplasms","Macrophage Activation","Macrophages","Mammary Neoplasms, Experimental","Mice, Inbred C57BL","Neoplasm Invasiveness","Prognosis","Mice, Knockout","Cell Cycle Proteins","Lactic Acid","Receptors, G-Protein-Coupled","Cell Line, Tumor","Mice","Tumor Microenvironment"],"keywords":["Metastasis","Cancer","Breast cancer","Cancer cell","Breast cancer metastasis","Cancer research","Macrophage","Cancer metastasis","Receptor","Medicine","Biology","Internal medicine","Biochemistry","In vitro","Lactate","Gpr132"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T15:57:47.198542Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}