{"doi":"10.1073/pnas.1509119112","title":"Phosphoregulatory protein 14-3-3 facilitates SAC1 transport from the endoplasmic reticulum","abstract":"<jats:title>Significance</jats:title>\n          <jats:p>Eukaryotes have evolved a multitrack transport process: the secretory pathway to route proteins to different destinations in a cell. Most cargo proteins originate on ribosomes bound to the endoplasmic reticulum (ER) and exit from the ER in membrane vesicles. The cytosolic coat protein complex II (COPII) coat is responsible for cargo protein sorting and vesicle budding from the ER. For some cargo proteins, additional cytosolic proteins serve to assist the core COPII machinery. One such cargo protein is the Sac1 lipid phosphatase, whose packaging into COPII vesicles depends upon the phosphopeptide binding protein, 14-3-3. Sac1 is essential to regulate cell signaling, division, and transport processes. We suggest that the 14-3-3 protein serves a regulatory role in the packaging of Sac1 into COPII vesicles.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2015,"id":17334,"datarank":1.7286086387344803,"base_score":3.912023005428146,"endowment":3.912023005428146,"self_citation_contribution":0.586803450814222,"citation_network_contribution":1.1418051879202584,"self_endowment_contribution":0.586803450814222,"citer_contribution":1.1418051879202584,"corpus_percentile":null,"corpus_rank":null,"citation_count":49,"citer_count":39,"citers_with_citation_signal":36,"citers_with_endowment":36,"datacite_reuse_total":25,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":124393,"name":"Jinzhi Wang","orcid":null,"position":1,"is_corresponding":false},{"id":124394,"name":"Anastasia Blagoveshchenskaya","orcid":null,"position":2,"is_corresponding":false},{"id":124395,"name":"Lillian Lim","orcid":null,"position":3,"is_corresponding":false},{"id":124396,"name":"M. S. Madhusudhan","orcid":null,"position":4,"is_corresponding":false},{"id":124397,"name":"Peter Mayinger","orcid":null,"position":5,"is_corresponding":false},{"id":71618,"name":"Randy Schekman","orcid":"0000-0001-8615-6409","position":6,"is_corresponding":false},{"id":124392,"name":"Kanika Bajaj Pahuja","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.912023005428146,"endowment":3.912023005428146,"datacite_reuse_total":25,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26056309","pmcid":"PMC4485137","openalex_id":"https://openalex.org/W1612371477","authors":[],"funders":[{"funder_name":"Howard Hughes Medical Institute","grant_id":"N/A","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM084088","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null},{"funder_name":"Wellcome 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protein interactions","Ubiquitin and proteasome pathways","Protein Tyrosine Phosphatases","Biology","Medicine","14-3-3 Proteins","Animals","COP-Coated Vesicles","COS Cells","Chlorocebus aethiops","Endoplasmic Reticulum","HeLa Cells","Humans","Membrane Proteins","Protein Binding","Recombinant Proteins"],"mesh_terms":["Animals","Chlorocebus aethiops","Endoplasmic Reticulum","HeLa Cells","Humans","Membrane Proteins","Protein Binding","Recombinant Proteins","COS Cells","COP-Coated Vesicles","14-3-3 Proteins","Hela Cells"],"keywords":["Endoplasmic reticulum","Cell biology","Chemistry","Biology","Reconstitution","14-3-3","Sac1","Adaptor Protein","Copii Vesicles"],"sdg_mappings":[],"linked_datasets":[{"doi":"10.6084/m9.figshare.26581937.v1","title":"Additional file 1 of Proteomic analysis of extracellular vesicles from tick hemolymph and uptake of extracellular vesicles by salivary glands and ovary 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