{"doi":"10.1073/pnas.1506415112","title":"Increasing intracellular trehalose is sufficient to confer desiccation tolerance to\n                    <i>Saccharomyces cerevisiae</i>","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Diverse organisms across taxa are desiccation tolerant, capable of surviving extreme water loss. Remarkably, desiccation-tolerant organisms can survive years without water. The study of desiccation tolerance has the potential to provide novel insights into many aspects of stress and stress responses. Additionally, the study of desiccation tolerance may generate biomedical (blood storage) and agricultural (drought tolerance) applications. The disaccharide, trehalose, is one of several factors predicted to mitigate the adverse effects of desiccation tolerance. Here, we establish the sufficiency of trehalose in the desiccation tolerance of budding yeast. This study provides insights into the in vivo potential of small chemical chaperones to act as stress effectors and informs on the potential for in vivo metabolism under extreme desiccation conditions.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2015,"id":659685,"datarank":0.7977179990766325,"base_score":5.318119993844216,"endowment":5.318119993844216,"self_citation_contribution":0.7977179990766325,"citation_network_contribution":0.0,"self_endowment_contribution":0.7977179990766325,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":203,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1290267,"name":"Lindsey Young","orcid":null,"position":1,"is_corresponding":false},{"id":268922,"name":"Douglas Fox","orcid":"0000-0001-9260-4079","position":2,"is_corresponding":false},{"id":218284,"name":"Carolyn R. 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Additionally, the study of desiccation tolerance may generate biomedical (blood storage) and agricultural (drought tolerance) applications. The disaccharide, trehalose, is one of several factors predicted to mitigate the adverse effects of desiccation tolerance. Here, we establish the sufficiency of trehalose in the desiccation tolerance of budding yeast. This study provides insights into the in vivo potential of small chemical chaperones to act as stress effectors and informs on the potential for in vivo metabolism under extreme desiccation conditions.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25918381","pmcid":"PMC4434740","openalex_id":null,"authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R01 AI051622","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"AI051622","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R37 AI051622","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM007232","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM066698","title":null},{"funder_name":"Howard Hughes Medical Institute","grant_id":"","title":null}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.pnas.org/content/pnas/112/19/6122.full.pdf","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1506415112","host_type":"publisher"}],"fields_of_study":[],"mesh_terms":["Cytoplasm","Saccharomyces cerevisiae","Water","Maltose","Trehalose","Disaccharides","Symporters","Monosaccharide Transport Proteins","Saccharomyces cerevisiae Proteins","Desiccation","Glyceraldehyde-3-Phosphate Dehydrogenase (Phosphorylating)","Promoter Regions, Genetic","Stress, Physiological"],"keywords":["Stress","Desiccation","Trehalose","Yeast","Anhydrobiosis"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T07:25:08.620243Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}