{"doi":"10.1073/pnas.1424632112","title":"Cross-talk and regulatory interactions between the essential response regulator RpaB and cyanobacterial circadian clock output","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>\n                    In cyanobacteria, genome-wide transcriptional oscillations and cell division are under the control of the global response regulator RpaA. Here we show that regulator of phycobilisome-associated B (RpaB), a closely related response regulator that is essential in the model cyanobacterium\n                    <jats:italic>Synechococcus elongatus</jats:italic>\n                    PCC 7942, is involved in complex regulatory interactions with the RpaA signaling system. RpaB influences circadian timing and cell dimensions by modulating the RpaA∼P levels and by controlling a subset of the RpaA target genes. Our results suggest that regulatory interactions between RpaA and RpaB are required for transmission of updated time information to the level of gene expression, paving the way to uncover regulatory mechanisms involved in integration of temporal and environmental information.\n                  </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2015,"id":686701,"datarank":0.6141516843333151,"base_score":4.0943445622221,"endowment":4.0943445622221,"self_citation_contribution":0.6141516843333151,"citation_network_contribution":0.0,"self_endowment_contribution":0.6141516843333151,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":59,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":450576,"name":"Joseph S. Boyd","orcid":null,"position":1,"is_corresponding":false},{"id":1793984,"name":"Raquel Cantos","orcid":null,"position":2,"is_corresponding":false},{"id":1793985,"name":"Paloma Salinas","orcid":null,"position":3,"is_corresponding":false},{"id":272270,"name":"Susan S. Golden","orcid":"0000-0002-4264-7019","position":4,"is_corresponding":false},{"id":1793986,"name":"Asuncion Contreras","orcid":null,"position":5,"is_corresponding":false},{"id":1793982,"name":"Javier Espinosa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cross-talk and regulatory interactions between the essential response regulator RpaB and cyanobacterial circadian clock output","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>\n                    In cyanobacteria, genome-wide transcriptional oscillations and cell division are under the control of the global response regulator RpaA. Here we show that regulator of phycobilisome-associated B (RpaB), a closely related response regulator that is essential in the model cyanobacterium\n                    <jats:italic>Synechococcus elongatus</jats:italic>\n                    PCC 7942, is involved in complex regulatory interactions with the RpaA signaling system. RpaB influences circadian timing and cell dimensions by modulating the RpaA∼P levels and by controlling a subset of the RpaA target genes. Our results suggest that regulatory interactions between RpaA and RpaB are required for transmission of updated time information to the level of gene expression, paving the way to uncover regulatory mechanisms involved in integration of temporal and environmental information.\n                  </jats:p>","is_dataset_classified":null,"base_score":4.0943445622221,"endowment":4.0943445622221,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25653337","pmcid":"PMC4343135","openalex_id":"https://openalex.org/W2052346751","authors":[],"funders":[{"funder_name":"HHS | NIH | National Institute of General Medical Sciences","grant_id":"R01GM062419","title":null},{"funder_name":"Spanish Ministry of Economy and Competitivity","grant_id":"BFU2012-33364","title":null},{"funder_name":"Generalitat Valenciana","grant_id":"ACOMP/2014/144","title":null},{"funder_name":"Generalitat Valenciana","grant_id":"GV/2014/073","title":null},{"funder_name":"European Molecular Biology Organization","grant_id":"ASTF 74-2013","title":null}],"total_grants":5,"fwci":3.7141,"citation_percentile":0.93955934,"influential_citations":0,"citation_trend":[{"year":2015,"count":3},{"year":2016,"count":7},{"year":2017,"count":9},{"year":2018,"count":8},{"year":2019,"count":5},{"year":2020,"count":7},{"year":2021,"count":2},{"year":2022,"count":4},{"year":2023,"count":6},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"closed","license":"http://www.pnas.org/site/misc/userlicense.xhtml","oa_locations":[{"url":"http://www.pnas.org/syndication/doi/10.1073/pnas.1424632112","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1424632112","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1424632112","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25653337","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4343135","host_type":"repository"},{"url":"http://hdl.handle.net/10045/58326","host_type":"repository"},{"url":"https://escholarship.org/uc/item/8g38v6pk","host_type":"repository"},{"url":"http://www.escholarship.org/uc/item/8g38v6pk","host_type":"repository"}],"fields_of_study":["Photosynthetic Processes and Mechanisms","Light effects on plants","Plant Stress Responses and Tolerance","Bacterial Proteins","Circadian Rhythm","Cyanobacteria","Genes, Bacterial","Phosphorylation"],"mesh_terms":["Cyanobacteria","Bacterial Proteins","Circadian Rhythm","Genes, Bacterial","Phosphorylation"],"keywords":["Regulator","Circadian clock","Response regulator","Biology","Effector","Cell biology","Circadian rhythm","Transcriptional regulation","Regulation of gene expression","Phosphorylation","Transcription factor","Genetics","Gene","Mutant","Neuroscience","Transcription regulation","Chronobiology","Signaling Network"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T20:14:10.903727Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}