{"doi":"10.1073/pnas.1417856112","title":"Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Sound frequency discrimination is crucial for daily activities throughout the animal kingdom. This process begins at the auditory peripheral organ known as the organ of Corti in mammals and basilar papilla in birds. This frequency tuning is facilitated by specific anatomical and physiological properties, including gradual changes in the shape of the mechanosensory hair cells and the total number of stereocilia per hair cell along the cochlea. Unlike in birds, the molecular mechanism(s) that establishes this tonotopic organization is not known in mammals. In this study, we provide in vivo evidence that Sonic Hedgehog signaling mediates regional identity of the developing cochlea in both mammals and birds, and this regional identity prefigures the tonotopic organization in the basilar papilla.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2015,"id":648206,"datarank":1.9253476981851152,"base_score":4.02535169073515,"endowment":4.02535169073515,"self_citation_contribution":0.6038027536102726,"citation_network_contribution":1.3215449445748426,"self_endowment_contribution":0.6038027536102726,"citer_contribution":1.3215449445748426,"corpus_percentile":null,"corpus_rank":null,"citation_count":55,"citer_count":44,"citers_with_citation_signal":38,"citers_with_endowment":38,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1689114,"name":"Ji-Hyun Ma","orcid":null,"position":1,"is_corresponding":false},{"id":410971,"name":"Harinarayana Ankamreddy","orcid":"0000-0002-2859-087X","position":2,"is_corresponding":false},{"id":1689115,"name":"Jeong-Oh Shin","orcid":null,"position":3,"is_corresponding":false},{"id":737297,"name":"Jae Young Choi","orcid":"0000-0001-9493-3458","position":4,"is_corresponding":false},{"id":279458,"name":"Doris K. Wu","orcid":"0000-0002-1400-3558","position":5,"is_corresponding":false},{"id":284079,"name":"Jinwoong Bok","orcid":"0000-0003-1958-1872","position":6,"is_corresponding":false},{"id":1689112,"name":"Eun Jin Son","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Conserved role of Sonic Hedgehog in tonotopic organization of the avian basilar papilla and mammalian cochlea","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Sound frequency discrimination is crucial for daily activities throughout the animal kingdom. This process begins at the auditory peripheral organ known as the organ of Corti in mammals and basilar papilla in birds. This frequency tuning is facilitated by specific anatomical and physiological properties, including gradual changes in the shape of the mechanosensory hair cells and the total number of stereocilia per hair cell along the cochlea. Unlike in birds, the molecular mechanism(s) that establishes this tonotopic organization is not known in mammals. In this study, we provide in vivo evidence that Sonic Hedgehog signaling mediates regional identity of the developing cochlea in both mammals and birds, and this regional identity prefigures the tonotopic organization in the basilar papilla.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25775517","pmcid":"PMC4378437","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Research Foundation of Korea","grant_id":"2013R1A1A2007622","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"2014R1A2A1A11051024","title":null},{"funder_name":"National Research Foundation of Korea","grant_id":"2013M3A9D5072551","title":null},{"funder_name":"Yonsei University College of Medicine","grant_id":"6-2014-0024","title":null}],"total_grants":4,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":"cc-by-nc-nd","oa_locations":[{"url":"https://www.pnas.org/content/pnas/112/12/3746.full.pdf","host_type":"publisher"},{"url":"http://www.pnas.org/syndication/doi/10.1073/pnas.1417856112","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1417856112","host_type":"publisher"},{"url":"https://ir.ymlib.yonsei.ac.kr/handle/22282913/139827","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4378437","host_type":"repository"}],"fields_of_study":[],"mesh_terms":["Cochlea","Organ of Corti","Notochord","Animals","Chickens","Mice","Hearing","Signal Transduction","Mechanotransduction, Cellular","Species Specificity","Phenotype","Hedgehog Proteins","Hair Cells, Auditory"],"keywords":["Frequency Discrimination","Regional Identity","A2m","Efnb2","Inhba"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T02:22:25.211495Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}