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This study is, to our knowledge, the first report of a transmembrane helix enabling dimerization of an adjacent intrinsically disordered sequence, which not only advances our understanding of the activation mechanism of ADAM protease, but also provides novel insights on the principles of membrane–protein interactions and their roles in transmembrane signaling.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2014,"id":610002,"datarank":0.515098080672772,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.0,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":633183,"name":"Sungyun Cho","orcid":"0009-0009-2690-2268","position":1,"is_corresponding":false},{"id":1568122,"name":"Pin-Chuan Su","orcid":null,"position":2,"is_corresponding":false},{"id":1178393,"name":"Bryan W. 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This study is, to our knowledge, the first report of a transmembrane helix enabling dimerization of an adjacent intrinsically disordered sequence, which not only advances our understanding of the activation mechanism of ADAM protease, but also provides novel insights on the principles of membrane–protein interactions and their roles in transmembrane signaling.</jats:p>","is_dataset_classified":null,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25349418","pmcid":"PMC4234582","openalex_id":"https://openalex.org/W2076404344","authors":[],"funders":[{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM084175","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"GM084175","title":null}],"total_grants":2,"fwci":2.183,"citation_percentile":0.87022535,"influential_citations":0,"citation_trend":[{"year":2015,"count":3},{"year":2016,"count":5},{"year":2017,"count":5},{"year":2018,"count":2},{"year":2019,"count":3},{"year":2021,"count":1},{"year":2022,"count":1},{"year":2023,"count":4},{"year":2025,"count":3},{"year":2026,"count":3}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.pnas.org/content/pnas/111/45/15987.full.pdf","host_type":"journal"},{"url":"https://www.pnas.org/content/pnas/111/45/15987.full.pdf","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1409354111","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1409354111","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25349418","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4234582","host_type":"repository"}],"fields_of_study":["Cell Adhesion Molecules Research","Monoclonal and Polyclonal Antibodies Research","HER2/EGFR in Cancer Research"],"mesh_terms":["ADAM10 Protein","Cell Membrane","Escherichia coli","Humans","Membrane Proteins","Recombinant Proteins","Signal Transduction","Protein Structure, Tertiary","ADAM Proteins","Amyloid Precursor Protein Secretases","Protein Multimerization"],"keywords":["Transmembrane domain","Ectodomain","Transmembrane protein","ADAM10","Cytoplasm","Chemistry","Biophysics","Membrane protein","Biology","Cell biology","Biochemistry","Disintegrin","Metalloproteinase","Membrane","Receptor","Enzyme","FRET","Intrinsic Disorder","Membrane Protein Dimerization"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T18:24:36.354808Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}