{"doi":"10.1073/pnas.1315508111","title":"Crumbs promotes expanded recognition and degradation by the SCF\n            <sup>Slimb/β-TrCP</sup>\n            ubiquitin ligase","abstract":"<jats:title>Significance</jats:title>\n          <jats:p>\n            Regulation of tissue growth is essential for metazoan development and adult homeostasis. The Hippo (Hpo) pathway is an evolutionarily conserved signaling cascade that has emerged as a crucial regulator of tissue size by virtue of its control of cell proliferation and cell death. Multiple epithelial architecture inputs converge on Hpo signaling, allowing tissues to quickly respond to disruptions in cell–cell and cell–matrix interactions. Here, we show that the polarity protein Crumbs promotes the apical localization and degradation of the Hpo pathway protein Expanded, by the SCF\n            <jats:sup>Slmb/β-TRCP</jats:sup>\n            ubiquitin ligase. This ubiquitin-dependent mechanism could potentially allow the dynamic regulation of Hpo signaling in response to changes in polarity.\n          </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2014,"id":23980,"datarank":2.0238377252361888,"base_score":4.07753744390572,"endowment":4.07753744390572,"self_citation_contribution":0.611630616585858,"citation_network_contribution":1.4122071086503307,"self_endowment_contribution":0.611630616585858,"citer_contribution":1.4122071086503307,"corpus_percentile":null,"corpus_rank":null,"citation_count":58,"citer_count":52,"citers_with_citation_signal":42,"citers_with_endowment":42,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":145291,"name":"Maxine Holder","orcid":null,"position":1,"is_corresponding":false},{"id":145292,"name":"David Frith","orcid":null,"position":2,"is_corresponding":false},{"id":145294,"name":"Ambrosius P. Snijders","orcid":null,"position":3,"is_corresponding":false},{"id":145296,"name":"Nicolas Tapon","orcid":null,"position":4,"is_corresponding":false},{"id":145290,"name":"Paulo Ribeiro","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.07753744390572,"endowment":4.07753744390572,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24778256","pmcid":"PMC4024906","openalex_id":"https://openalex.org/W2040509817","authors":[],"funders":[{"funder_name":"Cancer Research UK","grant_id":"17064","title":null}],"total_grants":1,"fwci":2.8928,"citation_percentile":0.90334728,"influential_citations":7,"citation_trend":[{"year":2014,"count":1},{"year":2015,"count":4},{"year":2016,"count":8},{"year":2017,"count":6},{"year":2018,"count":4},{"year":2019,"count":5},{"year":2020,"count":7},{"year":2021,"count":4},{"year":2022,"count":6},{"year":2023,"count":8},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.pnas.org/content/pnas/111/19/E1980.full.pdf","host_type":"journal"},{"url":"https://www.pnas.org/content/pnas/111/19/E1980.full.pdf","host_type":"BRONZE"},{"url":"https://www.pnas.org/content/pnas/111/19/E1980.full.pdf","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1315508111","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1315508111","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24778256","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4024906","host_type":"repository"}],"fields_of_study":["Hippo pathway signaling and YAP/TAZ","Wnt/β-catenin signaling in development and cancer","Ubiquitin and proteasome pathways","Biology","Medicine","Animals","Cell Cycle Proteins","Cell Membrane","Cell Polarity","Cells, Cultured","Drosophila Proteins","Drosophila melanogaster","Epithelial Cells","Gene Expression Regulation, Developmental","Genotype","Membrane Proteins","Nuclear Proteins","SKP Cullin F-Box Protein Ligases","Signal Transduction","Trans-Activators","Ubiquitin-Protein Ligases","YAP-Signaling Proteins"],"mesh_terms":["YAP-Signaling Proteins","Animals","Cell Membrane","Cells, Cultured","Drosophila melanogaster","Epithelial Cells","Genotype","Membrane Proteins","Nuclear Proteins","Signal Transduction","Trans-Activators","Cell Polarity","Gene Expression Regulation, Developmental","Cell Cycle Proteins","Drosophila Proteins","Ubiquitin-Protein Ligases","SKP Cullin F-Box Protein Ligases"],"keywords":["Ubiquitin ligase","Cell biology","Ubiquitin","Hippo signaling pathway","Regulator","Biology","Cell growth","Ubiquitin-Protein Ligases","Signal transduction","DNA ligase","Cell","Cell fate determination","Biochemistry","Transcription factor","Enzyme","Development","Drosophila"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-07T21:06:11.377237Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}