{"doi":"10.1073/pnas.1314121111","title":"TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Toll-like receptors (TLRs) that sense microbial or endogenous DNA and RNA have been well implicated in systemic lupus erythematosus (SLE), a multisystem disease characterized by an autoimmune response to nuclear antigens. In mice, both TLR8 and TLR9 control TLR7-mediated lupus, but it is unknown if they have an additive effect in controlling TLR7. We demonstrate that double TLR8/9-deficient mice have increased abnormalities characteristic of SLE and that both TLR8 and TLR9 keep under control TLR7-mediated lupus, but they act on different cell types. TLR8 controls TLR7 function on dendritic cells, and TLR9 restrains TLR7 response on B cells. These TLR interactions have to be taken into account when novel therapeutic approaches are developed that target the blocking of TLRs.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2014,"id":601508,"datarank":0.7266280629687888,"base_score":4.844187086458591,"endowment":4.844187086458591,"self_citation_contribution":0.7266280629687888,"citation_network_contribution":0.0,"self_endowment_contribution":0.7266280629687888,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":126,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1542351,"name":"Amanda Beatriz Macedo","orcid":null,"position":1,"is_corresponding":false},{"id":1542352,"name":"Annie Roussel-Queval","orcid":null,"position":2,"is_corresponding":false},{"id":1542353,"name":"Johnny Bonnardel","orcid":null,"position":3,"is_corresponding":false},{"id":267606,"name":"Sandrine Henri","orcid":"0000-0002-8980-9193","position":4,"is_corresponding":false},{"id":1542354,"name":"Olivier Demaria","orcid":null,"position":5,"is_corresponding":false},{"id":1542355,"name":"Lena Alexopoulou","orcid":null,"position":6,"is_corresponding":false},{"id":1542350,"name":"Benoit Desnues","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"TLR8 on dendritic cells and TLR9 on B cells restrain TLR7-mediated spontaneous autoimmunity in C57BL/6 mice","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Toll-like receptors (TLRs) that sense microbial or endogenous DNA and RNA have been well implicated in systemic lupus erythematosus (SLE), a multisystem disease characterized by an autoimmune response to nuclear antigens. In mice, both TLR8 and TLR9 control TLR7-mediated lupus, but it is unknown if they have an additive effect in controlling TLR7. We demonstrate that double TLR8/9-deficient mice have increased abnormalities characteristic of SLE and that both TLR8 and TLR9 keep under control TLR7-mediated lupus, but they act on different cell types. TLR8 controls TLR7 function on dendritic cells, and TLR9 restrains TLR7 response on B cells. These TLR interactions have to be taken into account when novel therapeutic approaches are developed that target the blocking of TLRs.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24474776","pmcid":null,"openalex_id":null,"authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.pnas.org/content/pnas/111/4/1497.full.pdf","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1314121111","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3910605","host_type":"repository"}],"fields_of_study":["Animals","Autoimmunity","B-Lymphocytes","Dendritic Cells","Flow Cytometry","Membrane Glycoproteins","Mice","Mice, Inbred C57BL","Polymerase Chain Reaction","Toll-Like Receptor 7","Toll-Like Receptor 8","Toll-Like Receptor 9"],"mesh_terms":["Animals","Autoimmunity","B-Lymphocytes","Dendritic Cells","Flow Cytometry","Membrane Glycoproteins","Mice","Mice, Inbred C57BL","Polymerase Chain Reaction","Toll-Like Receptor 7","Toll-Like Receptor 8","Toll-Like Receptor 9"],"keywords":["endosomal TLRs","innate immunity","knockout mice"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T16:34:36.186004Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}