{"doi":"10.1073/pnas.1312649110","title":"Structural analysis for glycolipid recognition by the C-type lectins Mincle and MCL","abstract":"<jats:title>Significance</jats:title><jats:p>Here we report the crystal structures of human C-type lectin receptors Mincle (macrophage inducible C-type “calcium-dependent” lectin; CLEC4E) and MCL (macrophage C-type lectin; CLEC4D), both of which are receptors for mycobacterial glycolipid adjuvant cord factor (also called trehalose-6,6′-dimycolate; TDM). Our structural and functional studies clearly reveal the simultaneous recognition of sugar and lipid moieties by Mincle and MCL, distinct from other C-type lectin receptors. Because better adjuvants are desired for enhancing vaccination effects of medical treatments for infectious diseases, cancer, and so forth, these structures provide a framework for the rational design of more effective adjuvants than TDM.</jats:p>","journal":"Proceedings of the National Academy of 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Toyonaga","orcid":null,"position":3,"is_corresponding":false},{"id":161233,"name":"Yuki Okabe","orcid":null,"position":4,"is_corresponding":false},{"id":161234,"name":"Aya Toji","orcid":null,"position":5,"is_corresponding":false},{"id":161235,"name":"Ryo Kanda","orcid":null,"position":6,"is_corresponding":false},{"id":161236,"name":"Yasunobu Miyake","orcid":null,"position":7,"is_corresponding":false},{"id":161237,"name":"Toyoyuki Ose","orcid":null,"position":8,"is_corresponding":false},{"id":161238,"name":"Sho Yamasaki","orcid":null,"position":9,"is_corresponding":false},{"id":161239,"name":"Katsumi Maenaka","orcid":null,"position":10,"is_corresponding":false},{"id":161229,"name":"Atsushi Furukawa","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.135798437050262,"endowment":5.135798437050262,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24101491","pmcid":"PMC3808641","openalex_id":"https://openalex.org/W2043173265","authors":[],"funders":[],"total_grants":0,"fwci":7.4776,"citation_percentile":0.97993652,"influential_citations":5,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":16},{"year":2015,"count":15},{"year":2016,"count":18},{"year":2017,"count":16},{"year":2018,"count":13},{"year":2019,"count":9},{"year":2020,"count":11},{"year":2021,"count":15},{"year":2022,"count":12},{"year":2023,"count":16},{"year":2024,"count":12},{"year":2025,"count":8},{"year":2026,"count":6}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.pnas.org/content/pnas/110/43/17438.full.pdf","host_type":"journal"},{"url":"https://www.pnas.org/content/pnas/110/43/17438.full.pdf","host_type":"BRONZE"},{"url":"https://www.pnas.org/content/pnas/110/43/17438.full.pdf","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1312649110","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1312649110","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24101491","host_type":"repository"},{"url":"https://hdl.handle.net/2115/56593","host_type":"repository"},{"url":"http://hdl.handle.net/2115/56593","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3808641","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3808641","host_type":"repository"},{"url":"https://eprints.lib.hokudai.ac.jp/repo/huscap/all/56593/WoS_63102_Furukarwa-Mincle-MCL_sup16.pdf","host_type":"repository"}],"fields_of_study":["Glycosylation and Glycoproteins Research","Immune Cell Function and Interaction","Escherichia coli research studies","Biology","Medicine","Chemistry","Amino Acid Sequence","Animals","Binding Sites","Calcium","Citric Acid","Cord Factors","Crystallography, X-Ray","Humans","Lectins, C-Type","Ligands","Mice","Molecular Sequence Data","Mutation","Protein Binding","Protein Structure, Secondary","Protein Structure, Tertiary","Receptors, Immunologic","Sequence Homology, Amino Acid","Surface Plasmon Resonance"],"mesh_terms":["Amino Acid Sequence","Animals","Binding Sites","Calcium","Cord Factors","Humans","Ligands","Molecular Sequence Data","Mutation","Protein Binding","Receptors, Immunologic","Sequence Homology, Amino Acid","Protein Structure, Secondary","Protein Structure, Tertiary","Crystallography, X-Ray","Citric Acid","Surface Plasmon Resonance","Lectins, C-Type","Mice"],"keywords":["Glycolipid","C-type lectin","Lectin","Receptor","Pattern recognition receptor","Biochemistry","Biology","Chemistry","Cell biology","Innate immune system","Mycobacteria","X-ray crystallography","innate immunity","Pattern-recognition receptors","Myeloid Cells"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life below water"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T22:38:46.246466Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}