{"doi":"10.1073/pnas.1311163110","title":"Whole chromosome gain does not in itself confer cancer-like chromosomal instability","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Aneuploidy, denoting cells with an abnormal number of chromosomes, is a common phenomenon in cancer. Another common finding in cancer cells is chromosomal instability, a condition in which cells change their chromosomal content at a high rate. It is clear that chromosomal instability can lead to aneuploidy, but whether the opposite is true has been much debated in the field of cancer biology. The concept that aneuploidy automatically triggers chromosomal instability has been propagated in the scientific literature in recent years. Here, we show that aneuploidy does not, on its own, lead to chromosomal instability, even when cells acquire chromosome alterations typical of cancer. This has important implications for understanding the role of aneuploidy in cancer development.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2013,"id":618201,"datarank":0.5375278407684165,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.0,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1594646,"name":"Yuesheng Jin","orcid":null,"position":1,"is_corresponding":false},{"id":526344,"name":"Bo Baldetorp","orcid":null,"position":2,"is_corresponding":false},{"id":849774,"name":"David Gisselsson","orcid":"0000-0002-0301-426X","position":3,"is_corresponding":false},{"id":849773,"name":"Anders Valind","orcid":"0000-0002-1654-6978","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Whole chromosome gain does not in itself confer cancer-like chromosomal instability","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Aneuploidy, denoting cells with an abnormal number of chromosomes, is a common phenomenon in cancer. Another common finding in cancer cells is chromosomal instability, a condition in which cells change their chromosomal content at a high rate. It is clear that chromosomal instability can lead to aneuploidy, but whether the opposite is true has been much debated in the field of cancer biology. The concept that aneuploidy automatically triggers chromosomal instability has been propagated in the scientific literature in recent years. Here, we show that aneuploidy does not, on its own, lead to chromosomal instability, even when cells acquire chromosome alterations typical of cancer. This has important implications for understanding the role of aneuploidy in cancer development.</jats:p>","is_dataset_classified":null,"base_score":3.58351893845611,"endowment":3.58351893845611,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24324169","pmcid":"PMC3876223","openalex_id":"https://openalex.org/W2042624690","authors":[],"funders":[],"total_grants":0,"fwci":2.2861,"citation_percentile":0.86575842,"influential_citations":0,"citation_trend":[{"year":2014,"count":4},{"year":2015,"count":5},{"year":2016,"count":6},{"year":2017,"count":3},{"year":2018,"count":7},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":2},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.pnas.org/content/pnas/110/52/21119.full.pdf","host_type":"journal"},{"url":"https://www.pnas.org/content/pnas/110/52/21119.full.pdf","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1311163110","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1311163110","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24324169","host_type":"repository"},{"url":"https://lup.lub.lu.se/record/4224930","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3876223","host_type":"repository"}],"fields_of_study":["Microtubule and mitosis dynamics","Genomic variations and chromosomal abnormalities","Genomics and Chromatin Dynamics"],"mesh_terms":["Aneuploidy","Flow Cytometry","Humans","Karyotyping","Mosaicism","Neoplasms","In Situ Hybridization, Fluorescence","Chromosome Disorders","Chromosomal Instability","Cell Line, Tumor"],"keywords":["Chromosome instability","Aneuploidy","Genome instability","Cancer","Biology","Chromosome","Chromothripsis","Genetics","Cancer cell","Chromosome engineering","Instability","Cancer research","Gene","DNA","DNA damage","Physics","Down syndrome","Neoplasia","Patau Syndrome","Edwards Syndrome"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Peace, Justice and strong institutions"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T03:42:47.353864Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}