{"doi":"10.1073/pnas.1304859110","title":"Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system","abstract":"<jats:title>Significance</jats:title>\n                  <jats:p>Thymocytes express a diverse repertoire of T-cell antigen receptors. Stringent selection processes eliminate autoreactive cells and guide useful thymocytes to develop into CD4 or CD8 lineages. Development always generates more CD4 than CD8 T cells, but it is not understood why. Our study used mathematics to investigate the basis of this asymmetric lineage development. Although similar numbers of CD4 and CD8 precursors start selection, our analysis revealed unexpectedly high death rates in developing thymocytes. In particular, CD8 precursors were more susceptible to death than CD4 lineage cells, and this was a major contributor to the high CD4:CD8 ratio of development.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2013,"id":647166,"datarank":0.6814942173405006,"base_score":4.543294782270004,"endowment":4.543294782270004,"self_citation_contribution":0.6814942173405006,"citation_network_contribution":0.0,"self_endowment_contribution":0.6814942173405006,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":93,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1685936,"name":"Iren Bains","orcid":null,"position":1,"is_corresponding":false},{"id":431986,"name":"Andrew J. 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Although similar numbers of CD4 and CD8 precursors start selection, our analysis revealed unexpectedly high death rates in developing thymocytes. In particular, CD8 precursors were more susceptible to death than CD4 lineage cells, and this was a major contributor to the high CD4:CD8 ratio of development.</jats:p>","is_dataset_classified":null,"base_score":4.543294782270004,"endowment":4.543294782270004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23858460","pmcid":"PMC3732981","openalex_id":"https://openalex.org/W2158450091","authors":[],"funders":[{"funder_name":"Medical Research Council","grant_id":"MC_U117573801","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_PC_13055","title":null},{"funder_name":"NIAID NIH HHS","grant_id":"R01AI093870","title":null},{"funder_name":"Medical Research Council","grant_id":"U117573801","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01AI093870-11","title":"Modeling the development, age structure and maintenance of T cell populations"}],"total_grants":5,"fwci":4.8537,"citation_percentile":0.95817308,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":11},{"year":2015,"count":13},{"year":2016,"count":11},{"year":2017,"count":7},{"year":2018,"count":6},{"year":2019,"count":9},{"year":2020,"count":9},{"year":2021,"count":6},{"year":2022,"count":8},{"year":2023,"count":4},{"year":2024,"count":5},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"CC BY","oa_locations":[{"url":"https://www.pnas.org/content/pnas/110/31/E2905.full.pdf","host_type":"journal"},{"url":"https://www.pnas.org/content/pnas/110/31/E2905.full.pdf","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1304859110","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1304859110","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23858460","host_type":"repository"},{"url":"http://discovery.ucl.ac.uk/1403398/","host_type":"repository"},{"url":"http://europepmc.org/articles/PMC3732981","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732981","host_type":"repository"},{"url":"https://eprints.gla.ac.uk/100323/1/100323.pdf","host_type":""},{"url":"https://dx.doi.org/10.1073/pnas.1304859110","host_type":""}],"fields_of_study":["T-cell and B-cell Immunology","Immune Cell Function and Interaction","Immunotherapy and Immune Responses","0301 basic medicine","0303 health sciences","03 medical and health sciences","Animals","CD4-CD8 Ratio","CD4-Positive T-Lymphocytes","CD8-Positive T-Lymphocytes","Cell Death","Histocompatibility Antigens Class I","Immunity, Cellular","Mice","Mice, Knockout","Thymocytes"],"mesh_terms":["Animals","Immunity, Cellular","Histocompatibility Antigens Class I","CD4-Positive T-Lymphocytes","CD4-CD8 Ratio","Cell Death","Mice, Knockout","CD8-Positive T-Lymphocytes","Mice","Thymocytes"],"keywords":["Thymocyte","CD8","Biology","Lineage (genetic)","Cytotoxic T cell","Programmed cell death","Cell biology","Negative selection","Apoptosis","Cellular differentiation","Immune system","T cell","Immunology","Genetics","In vitro","Gene","Cd8 T Cells","Cd4 T Cells","CD4-Positive T-Lymphocytes","Mice, Knockout","Immunity, Cellular","Mice","Thymocytes","Cell Death","Histocompatibility Antigens Class I","CD4-CD8 Ratio","Animals","CD8-Positive T-Lymphocytes"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T17:11:56.163520Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}