{"doi":"10.1073/pnas.130425197","title":"Enhancement of induced disease resistance by simultaneous activation of salicylate- and jasmonate-dependent defense pathways in\n            <i>Arabidopsis</i>\n            <i>thaliana</i>","abstract":"<jats:p>\n            The plant-signaling molecules salicylic acid (SA) and jasmonic acid (JA) play an important role in induced disease resistance pathways. Cross-talk between SA- and JA-dependent pathways can result in inhibition of JA-mediated defense responses. We investigated possible antagonistic interactions between the SA-dependent systemic acquired resistance (SAR) pathway, which is induced upon pathogen infection, and the JA-dependent induced systemic resistance (ISR) pathway, which is triggered by nonpathogenic\n            <jats:italic>Pseudomonas</jats:italic>\n            rhizobacteria. In\n            <jats:italic>Arabidopsis thaliana</jats:italic>\n            , SAR and ISR are effective against a broad spectrum of pathogens, including the foliar pathogen\n            <jats:italic>Pseudomonas syringae</jats:italic>\n            pv.\n            <jats:italic>tomato</jats:italic>\n            (\n            <jats:italic>Pst</jats:italic>\n            ). Simultaneous activation of SAR and ISR resulted in an additive effect on the level of induced protection against\n            <jats:italic>Pst</jats:italic>\n            . In\n            <jats:italic>Arabidopsis</jats:italic>\n            genotypes that are blocked in either SAR or ISR, this additive effect was not evident. Moreover, induction of ISR did not affect the expression of the SAR marker gene\n            <jats:italic>PR-1</jats:italic>\n            in plants expressing SAR. Together, these observations demonstrate that the SAR and the ISR pathway are compatible and that there is no significant cross-talk between these pathways. SAR and ISR both require the key regulatory protein NPR1. Plants expressing both types of induced resistance did not show elevated\n            <jats:italic>Npr1</jats:italic>\n            transcript levels, indicating that the constitutive level of NPR1 is sufficient to facilitate simultaneous expression of SAR and ISR. These results suggest that the enhanced level of protection is established through parallel activation of complementary, NPR1-dependent defense responses that are both active against\n            <jats:italic>Pst</jats:italic>\n            . Therefore, combining SAR and ISR provides an attractive tool for the improvement of disease control.\n          </jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2000,"id":25380,"datarank":12.045072240927922,"base_score":6.411818267709897,"endowment":6.411818267709897,"self_citation_contribution":0.9617727401564847,"citation_network_contribution":11.083299500771437,"self_endowment_contribution":0.9617727401564847,"citer_contribution":11.083299500771437,"corpus_percentile":null,"corpus_rank":null,"citation_count":608,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":149452,"name":"Erik A. M. de Swart","orcid":null,"position":1,"is_corresponding":false},{"id":149453,"name":"Johan A. van Pelt","orcid":null,"position":2,"is_corresponding":false},{"id":149454,"name":"Leendert C. van Loon","orcid":null,"position":3,"is_corresponding":false},{"id":149455,"name":"Corné M. J. Pieterse","orcid":null,"position":4,"is_corresponding":false},{"id":149451,"name":"Saskia C. M. van Wees","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":6.411818267709897,"endowment":6.411818267709897,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"10890883","pmcid":"PMC27013","openalex_id":"https://openalex.org/W1527275154","authors":[],"funders":[],"total_grants":0,"fwci":46.8552,"citation_percentile":0.99871005,"influential_citations":17,"citation_trend":[{"year":2012,"count":30},{"year":2013,"count":35},{"year":2014,"count":26},{"year":2015,"count":14},{"year":2016,"count":22},{"year":2017,"count":22},{"year":2018,"count":23},{"year":2019,"count":20},{"year":2020,"count":24},{"year":2021,"count":27},{"year":2022,"count":22},{"year":2023,"count":25},{"year":2024,"count":15},{"year":2025,"count":14},{"year":2026,"count":6}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/27013","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC27013","host_type":"GREEN"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/27013","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.130425197","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.130425197","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/10890883","host_type":"repository"},{"url":"https://dspace.library.uu.nl/handle/1874/388761","host_type":"repository"},{"url":"https://dspace.library.uu.nl/handle/1874/7713","host_type":"repository"}],"fields_of_study":["Plant-Microbe Interactions and Immunity","Plant Parasitism and Resistance","Plant Pathogenic Bacteria Studies","Biology","Medicine","Environmental Science","Arabidopsis","Arabidopsis Proteins","Cyclopentanes","Drug Synergism","Gene Expression","Oxylipins","Plant Diseases","Plant Growth Regulators","Plant Proteins","Pseudomonas","Salicylic Acid","Signal Transduction","Time Factors"],"mesh_terms":["Cyclopentanes","Drug Synergism","Plant Diseases","Plant Growth Regulators","Plant Proteins","Pseudomonas","Time Factors","Signal Transduction","Gene Expression","Arabidopsis","Salicylic Acid","Arabidopsis Proteins","Oxylipins"],"keywords":["Pseudomonas syringae","Jasmonic acid","NPR1","Systemic acquired resistance","Arabidopsis thaliana","Salicylic acid","Jasmonate","Plant defense against herbivory","Biology","Methyl jasmonate","Arabidopsis","Plant disease resistance","Signal transduction","Cell biology","Pathogen","Microbiology","Biochemistry","Gene","Mutant"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T04:14:31.280332Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}