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These findings identify a central role for Malt1-dependent RelB cleavage in canonical NF-κB activation and thereby provide a rationale for the targeting of Malt1 in immunomodulation and cancer treatment.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2011,"id":598410,"datarank":0.8208406010507213,"base_score":5.472270673671475,"endowment":5.472270673671475,"self_citation_contribution":0.8208406010507213,"citation_network_contribution":0.0,"self_endowment_contribution":0.8208406010507213,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":237,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":536427,"name":"Hendrik Nogai","orcid":"0000-0001-5743-1301","position":1,"is_corresponding":false},{"id":1533349,"name":"Christiane Pelzer","orcid":null,"position":2,"is_corresponding":false},{"id":870076,"name":"Maike Jaworski","orcid":"0000-0002-1855-5640","position":3,"is_corresponding":false},{"id":1533350,"name":"Katrin Cabalzar","orcid":null,"position":4,"is_corresponding":false},{"id":1533351,"name":"Jean-Enno Charton","orcid":null,"position":5,"is_corresponding":false},{"id":1533352,"name":"Montserrat Guzzardi","orcid":null,"position":6,"is_corresponding":false},{"id":1533353,"name":"Chantal Décaillet","orcid":null,"position":7,"is_corresponding":false},{"id":1533354,"name":"Michael Grau","orcid":null,"position":8,"is_corresponding":false},{"id":1529785,"name":"Bernd Dörken","orcid":null,"position":9,"is_corresponding":false},{"id":1533355,"name":"Peter Lenz","orcid":null,"position":10,"is_corresponding":false},{"id":840322,"name":"Georg Lenz","orcid":null,"position":11,"is_corresponding":false},{"id":833760,"name":"Margot Thome","orcid":"0000-0002-5656-2139","position":12,"is_corresponding":false},{"id":750176,"name":"Stephan Hailfinger","orcid":"0000-0003-0276-2263","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Malt1-dependent RelB cleavage promotes canonical NF-κB activation in lymphocytes and lymphoma cell lines","abstract":"<jats:p>The protease activity of the paracaspase Malt1 contributes to antigen receptor-mediated lymphocyte activation and lymphomagenesis. Malt1 activity is required for optimal NF-κB activation, but little is known about the responsible substrate(s). Here we report that Malt1 cleaved the NF-κB family member RelB after Arg-85. RelB cleavage induced its proteasomal degradation and specifically controlled DNA binding of RelA- or c-Rel–containing NF-κB complexes. Overexpression of RelB inhibited expression of canonical NF-κB target genes and led to impaired survival of diffuse large B-cell lymphoma cell lines characterized by constitutive Malt1 activity. These findings identify a central role for Malt1-dependent RelB cleavage in canonical NF-κB activation and thereby provide a rationale for the targeting of Malt1 in immunomodulation and cancer treatment.</jats:p>","is_dataset_classified":null,"base_score":5.472270673671475,"endowment":5.472270673671475,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21873235","pmcid":"PMC3167514","openalex_id":"https://openalex.org/W1998003228","authors":[],"funders":[],"total_grants":0,"fwci":8.0315,"citation_percentile":0.97873211,"influential_citations":0,"citation_trend":[{"year":2012,"count":27},{"year":2013,"count":23},{"year":2014,"count":19},{"year":2015,"count":19},{"year":2016,"count":26},{"year":2017,"count":15},{"year":2018,"count":26},{"year":2019,"count":14},{"year":2020,"count":10},{"year":2021,"count":16},{"year":2022,"count":7},{"year":2023,"count":12},{"year":2024,"count":8},{"year":2025,"count":8},{"year":2026,"count":5}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1105020108","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1105020108","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21873235","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3167514","host_type":"repository"},{"url":"https://iris.unil.ch/handle/iris/35773","host_type":"repository"},{"url":"https://serval.unil.ch/notice/serval:BIB_4C1E52575884","host_type":"repository"}],"fields_of_study":["NF-κB Signaling Pathways","Immune Response and Inflammation","Cell death mechanisms and regulation"],"mesh_terms":["Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein","Humans","Lymphocyte Activation","Lymphocytes","Neoplasm Proteins","NF-kappa B","Lymphoma, Large B-Cell, Diffuse","Caspases","Cell Line, Tumor","Transcription Factor RelB","Transcription Factor RelA"],"keywords":["RELB","Jurkat cells","NF-κB","Cancer research","Cell biology","Chemistry","Molecular biology","Cleavage (geology)","P50","Biology","Signal transduction","T cell","Gene","Transcription factor","Immune system","Genetics","Biochemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T15:39:24.942429Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}