{"doi":"10.1073/pnas.1101275108","title":"Methionine sulfoxide reductase A is a stereospecific methionine oxidase","abstract":"<jats:p>Methionine sulfoxide reductase A (MsrA) catalyzes the reduction of methionine sulfoxide to methionine and is specific for the S epimer of methionine sulfoxide. The enzyme participates in defense against oxidative stresses by reducing methionine sulfoxide residues in proteins back to methionine. Because oxidation of methionine residues is reversible, this covalent modification could also function as a mechanism for cellular regulation, provided there exists a stereospecific methionine oxidase. We show that MsrA itself is a stereospecific methionine oxidase, producing S-methionine sulfoxide as its product. MsrA catalyzes its own autooxidation as well as oxidation of free methionine and methionine residues in peptides and proteins. When functioning as a reductase, MsrA fully reverses the oxidations which it catalyzes.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2011,"id":687975,"datarank":0.6966586348712059,"base_score":4.6443908991413725,"endowment":4.6443908991413725,"self_citation_contribution":0.6966586348712059,"citation_network_contribution":0.0,"self_endowment_contribution":0.6966586348712059,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":103,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":706998,"name":"Zheng You","orcid":null,"position":1,"is_corresponding":false},{"id":786234,"name":"Geumsoo Kim","orcid":null,"position":2,"is_corresponding":false},{"id":337484,"name":"Rodney L. 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MsrA catalyzes its own autooxidation as well as oxidation of free methionine and methionine residues in peptides and proteins. When functioning as a reductase, MsrA fully reverses the oxidations which it catalyzes.</jats:p>","is_dataset_classified":null,"base_score":4.6443908991413725,"endowment":4.6443908991413725,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21670260","pmcid":"PMC3127874","openalex_id":"https://openalex.org/W2089626228","authors":[],"funders":[{"funder_name":"Intramural NIH HHS","grant_id":"","title":null},{"funder_name":"Intramural NIH HHS","grant_id":"","title":null}],"total_grants":2,"fwci":3.7678,"citation_percentile":0.94420492,"influential_citations":0,"citation_trend":[{"year":2012,"count":7},{"year":2013,"count":14},{"year":2014,"count":8},{"year":2015,"count":7},{"year":2016,"count":6},{"year":2017,"count":6},{"year":2018,"count":9},{"year":2019,"count":5},{"year":2020,"count":5},{"year":2021,"count":2},{"year":2022,"count":9},{"year":2023,"count":8},{"year":2024,"count":5},{"year":2025,"count":6},{"year":2026,"count":4}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.pnas.org/content/pnas/108/26/10472.full.pdf","host_type":"journal"},{"url":"https://www.pnas.org/content/pnas/108/26/10472.full.pdf","host_type":"publisher"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1101275108","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1101275108","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21670260","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3127874","host_type":"repository"}],"fields_of_study":["Redox biology and oxidative stress","Heme Oxygenase-1 and Carbon Monoxide","Endoplasmic Reticulum Stress and Disease","Biocatalysis","Chromatography, High Pressure Liquid","Mass Spectrometry","Methionine Sulfoxide Reductases","Oxidation-Reduction","Stereoisomerism","Substrate Specificity"],"mesh_terms":["Chromatography, High Pressure Liquid","Oxidation-Reduction","Mass Spectrometry","Stereoisomerism","Substrate Specificity","Methionine Sulfoxide Reductases","Biocatalysis"],"keywords":["MSRA","Methionine sulfoxide","Methionine sulfoxide reductase","Methionine","Sulfoxide","Stereospecificity","Chemistry","Biochemistry","Stereochemistry","Amino acid","Organic chemistry","Catalysis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-19T10:55:14.386648Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}