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This result has implications for the induction of ADCC responses by HIV vaccines.</jats:p>","journal":"Proceedings of the National Academy of Sciences","year":2011,"id":594577,"datarank":0.7515952941144385,"base_score":5.0106352940962555,"endowment":5.0106352940962555,"self_citation_contribution":0.7515952941144385,"citation_network_contribution":0.0,"self_endowment_contribution":0.7515952941144385,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":149,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1522135,"name":"Gamze Isitman","orcid":null,"position":1,"is_corresponding":false},{"id":1522137,"name":"Marjon Navis","orcid":null,"position":2,"is_corresponding":false},{"id":1522138,"name":"Marit Kramski","orcid":null,"position":3,"is_corresponding":false},{"id":1522140,"name":"Rob J. 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We then compared the ADCC responses to the same peptide epitope derived from the concurrent HIV sequence(s) expressed in circulating virus. In 9 of 13 epitopes studied, ADCC antibodies were unable to recognize the concurrent HIV sequence. Our studies suggest ADCC responses apply significant immune pressure on the virus. This result has implications for the induction of ADCC responses by HIV vaccines.</jats:p>","is_dataset_classified":null,"base_score":5.0106352940962555,"endowment":5.0106352940962555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21502492","pmcid":"PMC3088575","openalex_id":"https://openalex.org/W2021039830","authors":[],"funders":[{"funder_name":"NIAID NIH HHS","grant_id":"R21 AI081541","title":null}],"total_grants":1,"fwci":6.0829,"citation_percentile":0.9783751,"influential_citations":0,"citation_trend":[{"year":2012,"count":17},{"year":2013,"count":19},{"year":2014,"count":15},{"year":2015,"count":14},{"year":2016,"count":10},{"year":2017,"count":20},{"year":2018,"count":9},{"year":2019,"count":8},{"year":2020,"count":5},{"year":2021,"count":18},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":1},{"year":2026,"count":3}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088575","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3088575","host_type":"repository"},{"url":"https://pnas.org/doi/pdf/10.1073/pnas.1016048108","host_type":"publisher"},{"url":"https://doi.org/10.1073/pnas.1016048108","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21502492","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","Immune Cell Function and Interaction","T-cell and B-cell Immunology"],"mesh_terms":["Antibody-Dependent Cell Cytotoxicity","Epitopes","Base Sequence","Flow Cytometry","Humans","Killer Cells, Natural","Lymphocyte Activation","Molecular Sequence Data","Neutralization Tests","Plasmids","HIV-1","HIV Infections","Gene Products, env","Sequence Analysis, DNA","Epitope Mapping"],"keywords":["Antibody-dependent cell-mediated cytotoxicity","Epitope","Immune system","Antibody","Virology","Biology","Immunology","Virus","HIV vaccine","Vaccine trial","Monoclonal antibody"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T14:56:38.688299Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}